Practical synthesis of isocoumarins via Rh(III)-catalyzed C-H activation/annulation cascade.
Beilstein J Org Chem
; 19: 100-106, 2023.
Article
en En
| MEDLINE
| ID: mdl-36761471
ABSTRACT
Herein, we report an unprecedented Rh(III)-catalyzed C-H activation/annulation cascade of readily available enaminones with iodonium ylides towards the convenient synthesis of isocoumarins. This coupling system proceeds in useful chemical yields (up to 93%) via a cascade C-H activation, Rh-carbenoid migratory insertion and acid-promoted intramolecular annulation. The success of gram-scale reaction and diverse functionalization of isocoumarins demonstrated the synthetic utility of this protocol.
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01-internacional
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MEDLINE
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En
Revista:
Beilstein J Org Chem
Año:
2023
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Article