Reshaping the Ventricle From Within: MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) Ventriculoplasty in Swine.

Bruce, Christopher G; Khan, Jaffar M; Rogers, Toby; Yildirim, D Korel; Jaimes, Andrea E; Seemann, Felicia; Chen, Marcus Y; O'Brien, Kendall; Herzka, Daniel A; Schenke, William H; Eckhaus, Michael A; Potersnak, Amanda G; Campbell-Washburn, Adrienne; Babaliaros, Vasilis C; Greenbaum, Adam B; Lederman, Robert J

Bruce, Christopher G; Khan, Jaffar M; Rogers, Toby; Yildirim, D Korel; Jaimes, Andrea E; Seemann, Felicia; Chen, Marcus Y; O'Brien, Kendall; Herzka, Daniel A; Schenke, William H; Eckhaus, Michael A; Potersnak, Amanda G; Campbell-Washburn, Adrienne; Babaliaros, Vasilis C; Greenbaum, Adam B; Lederman, Robert J.

Afiliación

Bruce CG; Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Khan JM; Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Rogers T; Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Yildirim DK; MedStar Washington Hospital Center, Washington, DC, USA.
Jaimes AE; Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Seemann F; Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Chen MY; Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
O'Brien K; Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Herzka DA; Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Schenke WH; Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Eckhaus MA; Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Potersnak AG; Division of Veterinary Resources, National Institutes of Health, Bethesda, Maryland, USA.
Campbell-Washburn A; Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Babaliaros VC; Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Greenbaum AB; Structural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia, USA.
Lederman RJ; Structural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia, USA.

JACC Basic Transl Sci ; 8(1): 37-50, 2023 Jan.

Article en En | MEDLINE | ID: mdl-36777171

ABSTRACT

ABSTRACT

MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) is a transcatheter ventricular remodeling procedure. A transvenous tension element is placed within the walls of the beating left ventricle and shortened to narrow chamber dimensions. MIRTH uses 2 new techniques controlled intramyocardial guidewire navigation and EDEN (Electrocardiographic Radial Depth Navigation). MIRTH caused a sustained reduction in chamber dimensions in healthy swine. Midventricular implants approximated papillary muscles. MIRTH shortening improved myocardial contractility in cardiomyopathy in a dose-dependent manner up to a threshold beyond which additional shortening reduced performance. MIRTH may help treat dilated cardiomyopathy. Clinical investigation is warranted.

Palabras clave

CMR, cardiac magnetic resonance; CTO, chronic total occlusion; EDEN, electrocardiographic radial depth navigation; EDV, end-diastolic volume; ESPVR, end-systolic pressure-volume relationship; ESV, end-systolic volume; Ees, end-systolic elastance; LVEDP, left ventricular end-diastolic pressure; LVESP, left ventricular end systolic pressure; MIRTH, myocardial intramural remodeling by transvenous tether; PRSW, preload recruitable stroke work; PVA, pressure-volume area; cardiac repair; cardiomyopathy; heart failure/etiology/mortality/surgery; surgical ventricular restoration; ventricular remodeling; ventriculoplasty

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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