[Ultrastructural study on the model of human lung adenocarcinoma heterotransplanted to nude mice].

ABSTRACT

A human lung adenocarcinoma from surgical biopsy specimen was successfully heterotransplanted into nude mice and has been maintained for 40 generations. The experiments were made on 6-8 week old male or female nude mice with Swiss genetic background cultivated in specific pathogen-free condition. The electron microscopic observation on transplanted tumor of passages 2, 6, 12, 18 and 23 revealed that the ultrastructural features of this tumor were strictly maintained and no obvious change of differentiation was found. But there was a potential prone to regional squamous epithelial metaplasia in the transplanted tumor. The nude mice model of human lung adenocarcinoma so established can be used as a good experimental system of the homologous and reproducible human cancer for the study of basic medical sciences and chemotherapy of human lung carcinoma.