Nusinersen mitigates neuroinflammation in severe spinal muscular atrophy patients.
Commun Med (Lond)
; 3(1): 28, 2023 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-36792810
Spinal muscular atrophy (SMA) is an inherited disorder which leads to muscle weakening. Three therapies have recently been developed, including Nusinersen. However, the effect of SMA on the immune system and how this could be affected by Nusinersen is unknown. The immune system protects the body from infection and, in some disorders, misfunctions and damages the body in the absence of infection. Here, we analyze components of the immune system in body fluids from SMA patients before and after treatment with Nusinersen. The immune system was found to be more active in patients with more severe disease. Treatment with Nusinersen reduced the levels of some, but not all of these, components of the immune system. Thus, treatments that impact the immune system might improve symptoms in patients with SMA.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Commun Med (Lond)
Año:
2023
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Reino Unido