In vitro and in vivo validation of a new three-dimensional fringe projection-based device (AEVA-HE) dedicated to skin surface mapping.

ABSTRACT

BACKGROUND: Aging signs are much visible on the surface of the skin that presents different changes cheeks start to sag, more and deeper wrinkles appear, and pigmentation spots increase. Face diagnostic to recommend products includes assessing cutaneous micro-relief or the micro-depressive network on the face. Furthermore, there is an increasing demand for clinical and instrumental methods to prove the efficacy of anti-aging treatments. As a result, very accurate and sensitive three-dimensional (3D) devices are developed and validated to measure and quantify aging skin and to catch fine anti-aging products acting on wrinkles and fine lines. METHODS: AEVA-HE, a non-invasive 3D method based on fringe projection technology, is used to robustly characterize the skin micro-relief from a full-face acquisition and from multiple extracted zones of interest. In vitro and in vivo studies are conducted to assess the reproducibility of this system and its precision toward a standard fringe projection system, DermaTOP. RESULTS: The AEVA-HE successfully measured micro-relief and wrinkles and demonstrated the reproducibility of measurements.  AEVA-HE parameters were found highly correlated to DermaTOP. CONCLUSION: The present work illustrates the performance of the AEVA-HE device and its dedicated software kit as a precious tool for quantifying the major characteristics of wrinkles appearing with age and thus offers a high potential for assessing the effect of anti-wrinkling products.