Aspirin Use and Risk of Alzheimer's Disease: A 2-Sample Mendelian Randomization Study.
J Alzheimers Dis
; 92(3): 989-1000, 2023.
Article
en En
| MEDLINE
| ID: mdl-36846997
ABSTRACT
BACKGROUND:
Observational studies have shown inconsistent findings of the relationships between aspirin use and the risk of Alzheimer's disease (AD).OBJECTIVE:
Since residual confounding and reverse causality were challenging issues inherent in observational studies, we conducted a 2-sample Mendelian randomization analysis (MR) to investigate whether aspirin use was causally associated with the risk of AD.METHODS:
We conducted 2-sample MR analyses utilizing summary genetic association statistics to estimate the potential causal relationship between aspirin use and AD. Single-nucleotide variants associated with aspirin use in a genome-wide association study (GWAS) of UK Biobank were considered as genetic proxies for aspirin use. The GWAS summary-level data of AD were derived from a meta-analysis of GWAS data from the International Genomics of Alzheimer's Project (IGAP) stage I.RESULTS:
Univariable MR analysis based on these two large GWAS data sources showed that genetically proxied aspirin use was associated with a decreased risk of AD (Odds Ratio (OR) 0.87; 95%CI 0.77-0.99). In multivariate MR analyses, the causal estimates remained significant after adjusting for chronic pain, inflammation, heart failure (ORâ=â0.88, 95%CIâ=â0.78-0.98), or stroke (ORâ=â0.87, 95%CIâ=â0.77-0.99), but was attenuated when adjusting for coronary heart disease, blood pressure, and blood lipids.CONCLUSION:
Findings from this MR analysis suggest a genetic protective effect of aspirin use on AD, possibly influenced by coronary heart disease, blood pressure, and lipid levels.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad Coronaria
/
Enfermedad de Alzheimer
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
J Alzheimers Dis
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos