Isothiouronium-Mediated Conversion of Carboxylic Acids to Cyanomethyl Thioesters.

Tiefenbrunner, Irmgard; Brutiu, Bogdan R; Stopka, Tobias; Maulide, Nuno

Tiefenbrunner, Irmgard; Brutiu, Bogdan R; Stopka, Tobias; Maulide, Nuno.

Afiliación

Tiefenbrunner I; Institute of Organic Chemistry, University of Vienna, 1090 Vienna Austria.
Brutiu BR; Institute of Organic Chemistry, University of Vienna, 1090 Vienna Austria.
Stopka T; Institute of Organic Chemistry, University of Vienna, 1090 Vienna Austria.
Maulide N; Institute of Organic Chemistry, University of Vienna, 1090 Vienna Austria.

J Org Chem ; 88(6): 3941-3944, 2023 Mar 17.

Article en En | MEDLINE | ID: mdl-36853206

ABSTRACT

ABSTRACT

We report the development of an isothiouronium salt as a reagent for the operationally simple synthesis of cyanomethyl thioesters with high functional group tolerance and avoiding the use of thiols. Additionally, we show that the products can be engaged in amide synthesis in either a two-step or one-pot fashion.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2023 Tipo del documento: Article