Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel.

Gangwar, Shanti Pal; Yen, Laura Y; Yelshanskaya, Maria V; Sobolevsky, Alexander I

Gangwar, Shanti Pal; Yen, Laura Y; Yelshanskaya, Maria V; Sobolevsky, Alexander I.

Afiliación

Gangwar SP; Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168(th) Street, New York, NY 10032, USA.
Yen LY; Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168(th) Street, New York, NY 10032, USA; Cellular and Molecular Physiology and Biophysics Graduate Program, Columbia University Irving Medical Center, 630 West 168(th) Street, New York, NY 10032, USA.
Yelshanskaya MV; Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168(th) Street, New York, NY 10032, USA.
Sobolevsky AI; Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168(th) Street, New York, NY 10032, USA. Electronic address: as4005@cumc.columbia.edu.

Cell Rep ; 42(2): 112124, 2023 02 28.

Article en En | MEDLINE | ID: mdl-36857176

Asunto(s)

Anticonvulsivantes; Receptores de Ácido Kaínico; Receptores de Ácido Kaínico/metabolismo; Microscopía por Crioelectrón

Palabras clave

BPAM344; CP: Molecular biology; CP: Neuroscience; DNQX; GluK2; competitive antagonist; cryo-EM; iGluR; kainate receptor; negative allosteric modulator; perampanel; positive allosteric modulator

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Ácido Kaínico / Anticonvulsivantes Idioma: En Revista: Cell Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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