Mesenchymal stem cell-derived extracellular vesicles/exosome: A promising therapeutic strategy for intracerebral hemorrhage.
Regen Ther
; 22: 181-190, 2023 Mar.
Article
en En
| MEDLINE
| ID: mdl-36860266
ABSTRACT
Intracerebral hemorrhage (ICH) is the second largest type of stroke with high mortality and morbidity. The vast majority of survivors suffer from serious neurological defects. Despite the well-established etiology and diagnose, there is still some controversy over the ideal treatment strategy. MSC-based therapy has become an attractive and promising strategy for the treatment of ICH through immune regulation and tissue regeneration. However, accumulating studies have revealed that MSC-based therapeutic effects are mainly attributed to the paracrine properties of MSC, especially small extracellular vesicles/exosome (EVs/exo) which are considered to be the key mediators of the protective efficacy from MSCs. Moreover, some papers reported that MSC-EVs/exo have better therapeutic effects than MSCs. Therefore, EVs/exo has become a new choice for the treatment of ICH stroke in recent years. In this review, we mainly concentrate on the current research progress on the use of MSC-EVs/exo in the treatment of ICH and the existing challenges in their transplation from lab to clinical practice.
CAA, Cerebral amyloid angiopathy; Cell free therapy; EVs, extracellular vesicles; Exo, exosome; Exosomes; Extracellular vesicles; ICH, Intracerebral hemorrhage; Intracerebral hemorrhage; MSCs, Mesenchymal stromal cells; Mechanism; SAH, subarachnoid hemorrhage; db-ICH, Intracerebral hemorrhage (ICH) induced by diabetes
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Regen Ther
Año:
2023
Tipo del documento:
Article
País de afiliación:
China