Comparative Thermodynamics of the Reversible Self-Association of Therapeutic mAbs Reveal Opposing Roles for Linked Proton- and Ion-Binding Events.

Hopkins, Mandi M; Antonopoulos, Ioanna H; Parupudi, Arun; Bee, Jared S; Bain, David L

Hopkins, Mandi M; Antonopoulos, Ioanna H; Parupudi, Arun; Bee, Jared S; Bain, David L.

Afiliación

Hopkins MM; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 E. Montview Blvd., C-238, Aurora, CO, 80045, USA.
Antonopoulos IH; Formulation Development, Regeneron Pharmaceuticals, Tarrytown, NY, 10591, USA.
Parupudi A; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 E. Montview Blvd., C-238, Aurora, CO, 80045, USA.
Bee JS; Biophysical Characterization, KBI Biopharma, Louisville, CO, 80027, USA.
Bain DL; Department of Dosage Form Design and Development, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 20878, USA.

Pharm Res ; 40(6): 1383-1397, 2023 Jun.

Article en En | MEDLINE | ID: mdl-36869246

Asunto(s)

Anticuerpos Monoclonales; Protones; Anticuerpos Monoclonales/metabolismo; Cloruro de Sodio; Dispersión Dinámica de Luz; Termodinámica

Palabras clave

dynamic light scattering; interacting systems; monoclonal antibodies; nonideality; sedimentation velocity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protones / Anticuerpos Monoclonales Tipo de estudio: Risk_factors_studies Idioma: En Revista: Pharm Res Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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