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Amygdala and nucleus accumbens activation during reward anticipation moderates the association between life stressor frequency and depressive symptoms.
Fassett-Carman, Alyssa N; Moser, Amelia D; Ruzic, Luka; Neilson, Chiara; Jones, Jenna; Barnes-Horowitz, Sofia; Schneck, Christopher D; Kaiser, Roselinde H.
Afiliación
  • Fassett-Carman AN; University of Colorado Boulder, Institute of Cognitive Science, United States of America. Electronic address: alfa5796@colorado.edu.
  • Moser AD; University of Colorado Boulder, Department of Psychology and Neuroscience, United States of America.
  • Ruzic L; University of Colorado Boulder, Department of Psychology and Neuroscience, United States of America.
  • Neilson C; University of Colorado Boulder, Department of Psychology and Neuroscience, United States of America.
  • Jones J; University of Colorado Boulder, Institute of Cognitive Science, United States of America.
  • Barnes-Horowitz S; University of Colorado Boulder, Renée Crown Wellness Institute, United States of America.
  • Schneck CD; University of Colorado Anschutz Medical Campus, Department of Psychiatry, United States of America.
  • Kaiser RH; University of Colorado Boulder, Institute of Cognitive Science, United States of America; University of Colorado Boulder, Department of Psychology and Neuroscience, United States of America.
J Affect Disord ; 330: 309-318, 2023 06 01.
Article en En | MEDLINE | ID: mdl-36871909
BACKGROUND: Life stressors confer risk for depressive symptoms, but individuals vary in the extent of their sensitivity to life stressors. One protective factor may be an individual's level of reward sensitivity, e.g., a stronger neurobiological response to environmental rewards may mitigate emotional responses to stressors. However, the nature of neurobiological reward sensitivity that corresponds with stress resilience is unknown. Further, this model is untested in adolescence, when life stressor frequency and depression increase. METHODS: We tested the hypothesis that stronger reward-related activation in the left and right nucleus accumbens (NAc), amygdala, and medial prefrontal cortex (mPFC) attenuates the strength of the stress-depression relation. We measured BOLD activation throughout Win and Lose blocks of a monetary reward task, as well as during anticipation and outcome phases of the task. Participants (N = 151, ages 13-19) were recruited to be stratified on risk for mood disorders to enhance variance in depressive symptoms. RESULTS: Activation during anticipation of rewards in the bilateral amygdala and NAc, but not mPFC, buffered the association between life stressors and depressive symptoms. This buffering effect was not found for reward outcome activation or activation across Win blocks. CONCLUSIONS: Results highlight the importance of reward anticipation activation of subcortical structures in attenuating the stress-depression link, suggesting that reward motivation may be a cognitive mechanism through which this stress buffering occurs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recompensa / Estrés Psicológico / Depresión / Anticipación Psicológica / Amígdala del Cerebelo / Núcleo Accumbens Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: J Affect Disord Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recompensa / Estrés Psicológico / Depresión / Anticipación Psicológica / Amígdala del Cerebelo / Núcleo Accumbens Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: J Affect Disord Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos