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Early-Life Cardiovascular Risk Factor Trajectories and Vascular Aging in Midlife: A 30-Year Prospective Cohort Study.
Wang, Yang; Wang, Jie; Zheng, Xiao-Wei; Du, Ming-Fei; Zhang, Xi; Chu, Chao; Wang, Dan; Liao, Yue-Yuan; Ma, Qiong; Jia, Hao; Hu, Gui-Lin; Yan, Yu; Sun, Yue; Chen, Chen; Zhang, Xiao-Yu; Li, Hao; Zou, Ting; Niu, Ze-Jiaxin; Man, Zi-Yue; Wang, Lan; Luo, Wen-Jing; Wu, Guan-Ji; Kang, Yu-Ming; Chang, John; Delles, Christian; Lu, Yao; Mu, Jian-Jun.
Afiliación
  • Wang Y; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Wang J; Global Health Institute, School of Public Health (Y.W.), Xi'an Jiaotong University Health Science Center, China.
  • Zheng XW; Clinical Research Center, the Third Xiangya Hospital, Central South University, Changsha, China (J.W., Y.L.).
  • Du MF; Public Health Research Center and Department of Public Health and Preventive Medicine, Wuxi School of Medicine Jiangnan University, Jiangsu, China (X.-W.Z.).
  • Zhang X; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Chu C; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Wang D; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Liao YY; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Ma Q; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Jia H; Clinical Research Center, the Third Xiangya Hospital, Central South University, Changsha, China (J.W., Y.L.).
  • Hu GL; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Yan Y; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Sun Y; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Chen C; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Zhang XY; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Li H; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Zou T; Department of Cardiology, Northwest Women's and Children's Hospital of Xi'an (X.-Y.Z.), Xi'an Jiaotong University Health Science Center, China.
  • Niu ZJ; Department of Critical Care Medicine (H.L.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Man ZY; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Wang L; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Luo WJ; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Wu GJ; Department of Cardiology, Xi'an International Medical Center Hospital, China (L.W.).
  • Kang YM; Department of Cardiovascular Medicine (Y.W., M.-F.D., X.Z., C. Chu, D.W., Y.-Y.L., Q.M., H.J., G.-L.H., Y.Y., Y.S., C. Chen, T.Z., Z.-J.N., Z.-Y.M., W.-J.L., J.-J.M.), First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Chang J; Department of Cardiology, Xi'an Central Hospital of Xi'an Jiaotong University, China (G.-J.W.).
  • Delles C; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, China (Y.-M.K.).
  • Lu Y; Department of Medicine, Yale School of Medicine, New Haven, CT (J.C.).
  • Mu JJ; Department of Medicine, Veterans Administration Healthcare System, West Haven, CT (J.C.).
Hypertension ; 80(5): 1057-1066, 2023 05.
Article en En | MEDLINE | ID: mdl-36880389
ABSTRACT

BACKGROUND:

Vascular aging, as assessed by structural and functional arterial properties, is an independent predictor of cardiovascular outcomes. We aimed to explore the associations of individual cardiovascular risk factors from childhood to midlife and their accumulation over a 30-year span with vascular aging in midlife.

METHODS:

Using data from the ongoing cohort of Hanzhong Adolescent Hypertension study, 2180 participants aged 6 to 18 years at baseline were followed for over 30 years. Distinct trajectories of systolic blood pressure (SBP), body mass index (BMI), and heart rate from childhood to midlife were identified by group-based trajectory modeling. Vascular aging was assessed by carotid intima media thickness or brachial-ankle pulse wave velocity.

RESULTS:

We identified 4 distinct SBP trajectories, 3 distinct BMI trajectories, and 2 distinct heart rate trajectories from childhood to midlife. Persistently increasing SBP, high-increasing BMI, and high-stable heart rate were all shown to have a positive association with brachial-ankle pulse wave velocity in midlife. For carotid intima-media thickness, similar associations were observed for persistently increasing SBP and high-increasing body mass index. After further adjustment for SBP, body mass index and heart rate at the time of vascular assessment in 2017, associations were also observed for cardiovascular risk factor trajectories accumulation with brachial-ankle pulse wave velocity (ß, 0.656 [95% CI, 0.265-1.047]) and with carotid intima media thickness (ß, 0.045 [95% CI, 0.011-0.079]) in adulthood.

CONCLUSIONS:

Longitudinal exposure to individual cardiovascular risk factors from childhood to midlife and cardiovascular risk factor accumulation were associated with an increased risk of vascular aging in midlife. Our study lends support for early targeting of risk factors in order to prevent cardiovascular disease later in life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Humans Idioma: En Revista: Hypertension Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Humans Idioma: En Revista: Hypertension Año: 2023 Tipo del documento: Article País de afiliación: China