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WAO consensus on DEfinition of Food Allergy SEverity (DEFASE).
Arasi, Stefania; Nurmatov, Ulugbek; Dunn-Galvin, Audrey; Roberts, Graham; Turner, Paul J; Shinder, Sayantani B; Gupta, Ruchi; Eigenmann, Philippe; Nowak-Wegrzyn, Anna; Ansotegui, Ignacio J; Rivas, Montserrat Fernandez; Petrou, Stavros; Tanno, Luciana K; Vazquez-Ortiz, Marta; Vickery, Brian; Wong, Gary; Alvaro-Lozano, Montserrat; Asaria, Miqdad; Begin, Philippe; Bozzola, Martin; Boyle, Robert; Brough, Helen; Cardona, Victoria; Chinthrajah, R Sharon; Cianferoni, Antonella; Deschildre, Antoine; Fleischer, David; Gazzani, Flavio; Gerdts, Jennifer; Giannetti, Marilena; Greenhawt, Matthew; Guzmán, Maria Antonieta; Hossny, Elham; Kauppi, Paula; Jones, Carla; Lucidi, Francesco; Monge Ortega, Olga Patricia; Munblit, Daniel; Muraro, Antonella; Pajno, Giovanni; Podestà, Marcia; Rodriguez Del Rio, Pablo; Said, Maria; Santos, Alexandra; Shaker, Marcus; Szajewska, Hania; Venter, Carina; Warren, Cristopher; Winders, Tonya; Ebisawa, Motohiro.
Afiliación
  • Arasi S; Allergy Diseases Research Area, Pediatric Allergology Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
  • Nurmatov U; Division of Population Medicine, School of Medicine, Cardiff University, Wales, UK.
  • Dunn-Galvin A; Applied Psychology and Paediatrics and Child Health, University College Cork, Cork, Ireland.
  • Roberts G; Faculty of Medicine, University of Southampton, Southampton, UK.
  • Turner PJ; The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UK.
  • Shinder SB; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Gupta R; National Heart & Lung Institute, Imperial College London, London, UK.
  • Eigenmann P; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
  • Nowak-Wegrzyn A; Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA.
  • Ansotegui IJ; Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Rivas MF; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
  • Petrou S; Department of Pediatrics, Gynecology and Obstetrics, University Hospital of Geneva, Geneva, Switzerland.
  • Tanno LK; Allergy and Immunology, Department of Pediatrics, New York University School of Medicine, Langone Health, New York, NY, USA.
  • Vazquez-Ortiz M; Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
  • Vickery B; Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
  • Wong G; Allergy Department, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria San Carlos (IdISSC), Universidad Complutense, Madrid, Spain.
  • Alvaro-Lozano M; Nuffield Department of Primary Care Health Sciences, University of Oxford.
  • Asaria M; Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK.
  • Begin P; Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, England, UK.
  • Bozzola M; Division of Allergy, Department of Pulmonology, University Hospital of Montpellier, France.
  • Boyle R; Desbrest Institute of Epidemiology and Public Health, UA-11, INSERM University of Montpellier, France.
  • Brough H; WHO Collaborating Centre on Scientific Classification Support, Montpellier, France.
  • Cardona V; Section of Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Chinthrajah RS; Department of Pediatrics, Emory University, Atlanta, GA, USA.
  • Cianferoni A; Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
  • Deschildre A; Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain.
  • Fleischer D; Institut de Recerca Sant Joan de Deu, Barcelona, Spain.
  • Gazzani F; Universitat de Barcelona, Spain.
  • Gerdts J; Department of Health Policy, London School of Economics and Political Science, UK.
  • Giannetti M; Allergy, immunology and Rheumatology Division, Department of Pediatrics, CHU Sainte-Justine, Montreal, QC, Canada.
  • Greenhawt M; Allergy and Clinical immunology Division, Department of Medicine, Centre Hospitalier de l'Université de Montréal, QC, Canada.
  • Guzmán MA; Hospital Britanico de Buenos Aires Buenos Aires, Argentina.
  • Hossny E; National Heart and Lung Institute, Imperial College London, UK.
  • Kauppi P; Children's Allergy Service, Evelina Children's Hospital, Guy's and St. Thomas' Hospital, London, UK.
  • Jones C; Paediatric Allergy Group, Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, UK.
  • Lucidi F; Allergy Section, Department of Internal Medicine, Hospital Vall D'Hebron, Barcelona, Spain.
  • Monge Ortega OP; ARADyAL Research Network, Spain.
  • Munblit D; Sean N Parker Center for Allergy and Asthma Research, Stanford University.
  • Muraro A; The Children's Hospital of Philadelphia, The University of Pennsylvania, Philadelphia, PA, United States.
  • Pajno G; CHU Lille, Univ Lille, Pediatric Allergy and Pulmonology Unit, Hôpital Jeanne de Flandre, 59000 Lille, France.
  • Podestà M; Section of Pediatric Allergy & Immunology, Children's Hospital Colorado, USA.
  • Rodriguez Del Rio P; University of Colorado School of Medicine, USA.
  • Said M; Departement of Economics and Law, University of Rome La Sapienza, Italy.
  • Santos A; Executive Director, Food Allergy Canada, Toronto, Ontario, Canada.
  • Shaker M; Departement of Economics and Law, University of Rome La Sapienza, Italy.
  • Szajewska H; Section of Allergy and Immunology, Children's Hospital Colorado, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
  • Venter C; Immunology and Allergy Service, Clinical Hospital University of Chile, Santiago, Chile.
  • Warren C; Pediatric Allergy, Immunology and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.
  • Winders T; University of Helsinki and Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
  • Ebisawa M; Chief Executive of Patient Organisation, Allergy UK, London, UK.
World Allergy Organ J ; 16(3): 100753, 2023 Mar.
Article en En | MEDLINE | ID: mdl-36910595
ABSTRACT

Background:

While several scoring systems for the severity of anaphylactic reactions have been developed, there is a lack of consensus on definition and categorisation of severity of food allergy disease as a whole.

Aim:

To develop an international consensus on the severity of food allergy (DEfinition of Food Allergy Severity, DEFASE) scoring system, to be used globally. Methods Phase 1 We conducted a mixed-method systematic review (SR) of 11 databases for published and unpublished literature on severity of food allergy management and set up a panel of international experts. Phase 2 Based on our findings in Phase 1, we drafted statements for a two-round modified electronic Delphi (e-Delphi) survey. A purposefully selected multidisciplinary international expert panel on food allergy (n = 60) was identified and sent a structured questionnaire, including a set of statements on different domains of food allergy severity related to symptoms, health-related quality of life, and economic impact. Participants were asked to score their agreement on each statement on a 5-point Likert scale ranging from "strongly agree" to "strongly disagree". Median scores and percentage agreements were calculated. Consensus was defined a priori as being achieved if 70% or more of panel members rated a statement as "strongly agree" to "agree" after the second round. Based on feedback, 2 additional online voting rounds were conducted.

Results:

We received responses from 92% of Delphi panel members in round 1 and 85% in round 2. Consensus was achieved on the overall score and in all of the 5 specific key domains as essential components of the DEFASE score.

Conclusions:

The DEFASE score is the first comprehensive grading of food allergy severity that considers not only the severity of a single reaction, but the whole disease spectrum. An international consensus has been achieved regarding a scoring system for food allergy disease. It offers an evaluation grid, which may help to rate the severity of food allergy. Phase 3 will involve validating the scoring system in research settings, and implementing it in clinical practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Qualitative_research Aspecto: Patient_preference Idioma: En Revista: World Allergy Organ J Año: 2023 Tipo del documento: Article País de afiliación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Qualitative_research Aspecto: Patient_preference Idioma: En Revista: World Allergy Organ J Año: 2023 Tipo del documento: Article País de afiliación: Italia