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Safety and Efficacy of Topical Calcineurin Inhibitors in the Treatment of Facial and Genital Psoriasis: A Systematic Review.
Amiri, Diva; Schwarz, Christopher Willy; Gether, Lise; Skov, Lone.
Afiliación
  • Amiri D; Copenhagen Research Group for Inflammatory Skin (CORGIS), Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
  • Schwarz CW; Copenhagen Research Group for Inflammatory Skin (CORGIS), Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
  • Gether L; Copenhagen Research Group for Inflammatory Skin (CORGIS), Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
  • Skov L; Copenhagen Research Group for Inflammatory Skin (CORGIS), Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. Lone.Skov.02@regionh.dk.
Acta Derm Venereol ; 103: adv00890, 2023 Mar 14.
Article en En | MEDLINE | ID: mdl-36916954
Facial and genital psoriasis impairs quality of life and is challenging to treat because of increased percutaneous penetration and, consequently, increased risk of adverse effects. Topical calcineurin inhibitors are recognized as a valid off-label treatment for these sensitive skin areas, but data on safety and efficacy are limited. This systematic review of the literature included 24 of 3,322 studies (5 randomized controlled trials, 9 open-label studies, 2 case series and 8 case reports). All studies demonstrated positive efficacy; 11 studies found statistically significant reductions in psoriasis severity. Local stinging, burning and itching were the most common short-term adverse effects and were reported in 18 studies. Topical calcineurin inhibitors appear to have an important role in the treatment of facial and genital psoriasis. The drugs are effective and generally well-tolerated with few adverse effects.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Enfermedades de la Piel / Fármacos Dermatológicos Tipo de estudio: Clinical_trials / Diagnostic_studies / Systematic_reviews Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Acta Derm Venereol Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suecia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Enfermedades de la Piel / Fármacos Dermatológicos Tipo de estudio: Clinical_trials / Diagnostic_studies / Systematic_reviews Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Acta Derm Venereol Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suecia