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Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease.
Young, William J; Haessler, Jeffrey; Benjamins, Jan-Walter; Repetto, Linda; Yao, Jie; Isaacs, Aaron; Harper, Andrew R; Ramirez, Julia; Garnier, Sophie; van Duijvenboden, Stefan; Baldassari, Antoine R; Concas, Maria Pina; Duong, ThuyVy; Foco, Luisa; Isaksen, Jonas L; Mei, Hao; Noordam, Raymond; Nursyifa, Casia; Richmond, Anne; Santolalla, Meddly L; Sitlani, Colleen M; Soroush, Negin; Thériault, Sébastien; Trompet, Stella; Aeschbacher, Stefanie; Ahmadizar, Fariba; Alonso, Alvaro; Brody, Jennifer A; Campbell, Archie; Correa, Adolfo; Darbar, Dawood; De Luca, Antonio; Deleuze, Jean-François; Ellervik, Christina; Fuchsberger, Christian; Goel, Anuj; Grace, Christopher; Guo, Xiuqing; Hansen, Torben; Heckbert, Susan R; Jackson, Rebecca D; Kors, Jan A; Lima-Costa, Maria Fernanda; Linneberg, Allan; Macfarlane, Peter W; Morrison, Alanna C; Navarro, Pau; Porteous, David J; Pramstaller, Peter P; Reiner, Alexander P.
Afiliación
  • Young WJ; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.
  • Haessler J; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK.
  • Benjamins JW; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Repetto L; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
  • Yao J; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.
  • Isaacs A; Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Harper AR; Dept. of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.
  • Ramirez J; Maastricht Center for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands.
  • Garnier S; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.
  • van Duijvenboden S; Wellcome Centre for Human Genetics, Roosevelt Drive, Oxford, UK.
  • Baldassari AR; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.
  • Concas MP; Institute of Cardiovascular Sciences, University of College London, London, UK.
  • Duong T; Aragon Institute of Engineering Research, University of Zaragoza, Zaragoza, Spain and Center of Biomedical Research Network, Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain.
  • Foco L; Sorbonne Universite, INSERM, UMR-S1166, Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics & Pathophysiology of Cardiovascular Disease, Paris, 75013, France.
  • Isaksen JL; ICAN Institute for Cardiometabolism and Nutrition, Paris, 75013, France.
  • Mei H; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.
  • Noordam R; Institute of Cardiovascular Sciences, University of College London, London, UK.
  • Nursyifa C; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Richmond A; Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
  • Santolalla ML; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Sitlani CM; Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
  • Soroush N; Laboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Thériault S; Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
  • Trompet S; Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
  • Aeschbacher S; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Ahmadizar F; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.
  • Alonso A; Department of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Brody JA; Emerge, Emerging Diseases and Climate Change Research Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, 15152, Peru.
  • Campbell A; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Correa A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Darbar D; Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
  • De Luca A; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec, QC, Canada.
  • Deleuze JF; Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
  • Ellervik C; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Fuchsberger C; Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Goel A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Grace C; Julius Global Health, University Utrecht Medical Center, Utrecht, the Netherlands.
  • Guo X; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Hansen T; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Heckbert SR; Usher Institute, University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, UK.
  • Jackson RD; Health Data Research UK, University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, UK.
  • Kors JA; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.
  • Lima-Costa MF; Departments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.
  • Linneberg A; Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
  • Macfarlane PW; Cardiothoracovascular Department, Division of Cardiology, Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste, Trieste, Italy.
  • Morrison AC; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France.
  • Navarro P; Laboratory of Excellence GENMED (Medical Genomics), Paris, France.
  • Porteous DJ; Centre d'Etude du Polymorphisme Humain, Fondation Jean Dausset, Paris, France.
  • Pramstaller PP; Department of Data and Data Support, Region Zealand, 4180, Sorø, Denmark.
  • Reiner AP; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2100, Copenhagen, Denmark.
Nat Commun ; 14(1): 1411, 2023 03 14.
Article en En | MEDLINE | ID: mdl-36918541
ABSTRACT
The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Bloqueo Atrioventricular Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Bloqueo Atrioventricular Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido