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Evaluation and deployment of isotype-specific salivary antibody assays for detecting previous SARS-CoV-2 infection in children and adults.
Thomas, Amy C; Oliver, Elizabeth; Baum, Holly E; Gupta, Kapil; Shelley, Kathryn L; Long, Anna E; Jones, Hayley E; Smith, Joyce; Hitchings, Benjamin; di Bartolo, Natalie; Vasileiou, Kate; Rabi, Fruzsina; Alamir, Hanin; Eghleilib, Malak; Francis, Ore; Oliver, Jennifer; Morales-Aza, Begonia; Obst, Ulrike; Shattock, Debbie; Barr, Rachael; Collingwood, Lucy; Duale, Kaltun; Grace, Niall; Livera, Guillaume Gonnage; Bishop, Lindsay; Downing, Harriet; Rodrigues, Fernanda; Timpson, Nicholas; Relton, Caroline L; Toye, Ashley; Woolfson, Derek N; Berger, Imre; Goenka, Anu; Davidson, Andrew D; Gillespie, Kathleen M; Williams, Alistair J K; Bailey, Mick; Brooks-Pollock, Ellen; Finn, Adam; Halliday, Alice.
Afiliación
  • Thomas AC; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. amyc.thomas@bristol.ac.uk.
  • Oliver E; Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK. amyc.thomas@bristol.ac.uk.
  • Baum HE; Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
  • Gupta K; Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
  • Shelley KL; School of Biochemistry, University of Bristol, Bristol, UK.
  • Long AE; BrisSynBio, University of Bristol, Bristol, UK.
  • Jones HE; Imophoron Ltd, Science Creates, Old Market, Midland Road, Bristol, UK.
  • Smith J; School of Biochemistry, University of Bristol, Bristol, UK.
  • Hitchings B; BrisSynBio, University of Bristol, Bristol, UK.
  • di Bartolo N; School of Chemistry, University of Bristol, Bristol, UK.
  • Vasileiou K; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Rabi F; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Alamir H; Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
  • Eghleilib M; Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
  • Francis O; School of Biochemistry, University of Bristol, Bristol, UK.
  • Oliver J; NIHR Blood and Transplant Research Unit in Red Cell Products, University of Bristol, Bristol, UK.
  • Morales-Aza B; School of Biochemistry, University of Bristol, Bristol, UK.
  • Obst U; School of Biochemistry, University of Bristol, Bristol, UK.
  • Shattock D; Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
  • Barr R; Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
  • Collingwood L; Bristol Veterinary School, University of Bristol, Bristol, UK.
  • Duale K; Bristol Vaccine Centre, Population Health Sciences, University of Bristol, Bristol, UK.
  • Grace N; Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
  • Livera GG; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
  • Bishop L; Bristol Bioresource Laboratories, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Downing H; Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
  • Rodrigues F; Bristol Royal Hospital for Children, University Hospitals Bristol and Weston NHS Foundation Trust, Upper Maudlin Street, Bristol, BS2 8BJ, UK.
  • Timpson N; Bristol Vaccine Centre, Population Health Sciences, University of Bristol, Bristol, UK.
  • Relton CL; Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
  • Toye A; Bristol Vaccine Centre, Population Health Sciences, University of Bristol, Bristol, UK.
  • Woolfson DN; Bristol Vaccine Centre, Population Health Sciences, University of Bristol, Bristol, UK.
  • Berger I; Bristol Vaccine Centre, Population Health Sciences, University of Bristol, Bristol, UK.
  • Goenka A; NIHR Bristol Biomedical Research Centre, University of Bristol, Bristol, UK.
  • Davidson AD; Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
  • Gillespie KM; Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal.
  • Williams AJK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Bailey M; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
  • Brooks-Pollock E; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
  • Finn A; School of Biochemistry, University of Bristol, Bristol, UK.
  • Halliday A; NIHR Blood and Transplant Research Unit in Red Cell Products, University of Bristol, Bristol, UK.
Commun Med (Lond) ; 3(1): 37, 2023 Mar 15.
Article en En | MEDLINE | ID: mdl-36922542
If a person has been previously infected with SARS-CoV-2 they will produce specific proteins, called antibodies. These are present in the saliva and blood. Saliva is easier to obtain than blood, so we developed and evaluated six tests that detect SARS-CoV-2 antibodies in saliva in children and adults. Some tests detected antibodies to a particular protein made by SARS-CoV-2 called the spike protein, and these tests worked best. The most accurate results were obtained by using a combination of tests. Similar tests could also be developed to detect other respiratory infections which will enable easier identification of infected individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Commun Med (Lond) Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Commun Med (Lond) Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido