Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design.

Yu, Yang; Huang, Junhong; He, Hu; Han, Jing; Ye, Geyan; Xu, Tingyang; Sun, Xianqiang; Chen, Xiumei; Ren, Xiaoming; Li, Chunlai; Li, Huijuan; Huang, Wei; Liu, Yangyang; Wang, Xinjuan; Gao, Yongzhi; Cheng, Nianhe; Guo, Na; Chen, Xibo; Feng, Jianxia; Hua, Yuxia; Liu, Chong; Zhu, Guoyun; Xie, Zhi; Yao, Lili; Zhong, Wenge; Chen, Xinde; Liu, Wei; Li, Hailong

Yu, Yang; Huang, Junhong; He, Hu; Han, Jing; Ye, Geyan; Xu, Tingyang; Sun, Xianqiang; Chen, Xiumei; Ren, Xiaoming; Li, Chunlai; Li, Huijuan; Huang, Wei; Liu, Yangyang; Wang, Xinjuan; Gao, Yongzhi; Cheng, Nianhe; Guo, Na; Chen, Xibo; Feng, Jianxia; Hua, Yuxia; Liu, Chong; Zhu, Guoyun; Xie, Zhi; Yao, Lili; Zhong, Wenge; Chen, Xinde; Liu, Wei; Li, Hailong.

Afiliación

Yu Y; Tencent AI Lab, Tencent, Shenzhen 518057, China.
Huang J; Tencent AI Lab, Tencent, Shenzhen 518057, China.
He H; Regor Therapeutics Group, Shanghai, 201210, China.
Han J; Regor Therapeutics Group, Shanghai, 201210, China.
Ye G; Tencent AI Lab, Tencent, Shenzhen 518057, China.
Xu T; Tencent AI Lab, Tencent, Shenzhen 518057, China.
Sun X; Regor Therapeutics Group, Shanghai, 201210, China.
Chen X; Regor Therapeutics Group, Shanghai, 201210, China.
Ren X; Regor Therapeutics Group, Shanghai, 201210, China.
Li C; Regor Therapeutics Group, Shanghai, 201210, China.
Li H; Regor Therapeutics Group, Shanghai, 201210, China.
Huang W; Regor Therapeutics Group, Shanghai, 201210, China.
Liu Y; Regor Therapeutics Group, Shanghai, 201210, China.
Wang X; Regor Therapeutics Group, Shanghai, 201210, China.
Gao Y; Regor Therapeutics Group, Shanghai, 201210, China.
Cheng N; Regor Therapeutics Group, Shanghai, 201210, China.
Guo N; BioDuro-Sundia, Shanghai, 200131, China.
Chen X; BioDuro-Sundia, Shanghai, 200131, China.
Feng J; BioDuro-Sundia, Beijing, 102200, China.
Hua Y; BioDuro-Sundia, Beijing, 102200, China.
Liu C; BioDuro-Sundia, Beijing, 102200, China.
Zhu G; Regor Therapeutics Group, Shanghai, 201210, China.
Xie Z; Regor Therapeutics Group, Shanghai, 201210, China.
Yao L; Regor Therapeutics Group, Shanghai, 201210, China.
Zhong W; Regor Therapeutics Group, Shanghai, 201210, China.
Chen X; Tencent AI Lab, Tencent, Shenzhen 518057, China.
Liu W; Tencent AI Lab, Tencent, Shenzhen 518057, China.
Li H; Regor Therapeutics Group, Shanghai, 201210, China.

ACS Med Chem Lett ; 14(3): 297-304, 2023 Mar 09.

Article en En | MEDLINE | ID: mdl-36923916

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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