Ursonic acid from Artemisia montana exerts anti-diabetic effects through anti-glycating properties, and by inhibiting PTP1B and activating the PI3K/Akt signaling pathway in insulin-resistant C2C12 cells.

Ali, Md Yousof; Park, Se Eun; Seong, Su Hui; Zamponi, Gerald W; Jung, Hyun Ah; Choi, Jae Sue

Ursonic acid from Artemisia montana exerts anti-diabetic effects through anti-glycating properties, and by inhibiting PTP1B and activating the PI3K/Akt signaling pathway in insulin-resistant C2C12 cells.

Ali, Md Yousof; Park, Se Eun; Seong, Su Hui; Zamponi, Gerald W; Jung, Hyun Ah; Choi, Jae Sue.

Afiliación

Ali MY; Department of Clinical Neurosciences, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Park SE; Department of Food and Life Science, Pukyong National University, Busan, 48513, Republic of Korea.
Seong SH; Department of Food and Life Science, Pukyong National University, Busan, 48513, Republic of Korea; Division of Natural Products Research, Honam National Institute of Biological Resource, Mokpo, 58762, Republic of Korea.
Zamponi GW; Department of Clinical Neurosciences, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Jung HA; Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju, 54896, Republic of Korea. Electronic address: jungha@jbnu.ac.kr.
Choi JS; Department of Food and Life Science, Pukyong National University, Busan, 48513, Republic of Korea. Electronic address: choijs@pknu.ac.kr.

Chem Biol Interact ; 376: 110452, 2023 May 01.

Article en En | MEDLINE | ID: mdl-36933777

Asunto(s)

Artemisia; Diabetes Mellitus; Insulinas; Humanos; Lactante; Hipoglucemiantes/farmacología; alfa-Glucosidasas/metabolismo; Inhibidores de Glicósido Hidrolasas/química; Inhibidores de Glicósido Hidrolasas/farmacología; Proteínas Proto-Oncogénicas c-akt/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Monoéster Fosfórico Hidrolasas/metabolismo; Cinética; Artemisia/química; Artemisia/metabolismo; Simulación del Acoplamiento Molecular; Glucógeno Sintasa Quinasa 3/metabolismo; Montana; Diabetes Mellitus/tratamiento farmacológico; Transducción de Señal; Proteína Tirosina Fosfatasa no Receptora Tipo 1

Palabras clave

Anti-glycation; Artemisia montana; Insulin signaling; Molecular docking; PTP1B; Ursonic acid

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artemisia / Diabetes Mellitus / Insulinas Tipo de estudio: Prognostic_studies Límite: Humans / Infant País/Región como asunto: America do norte Idioma: En Revista: Chem Biol Interact Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Irlanda

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