Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients.
BMC Gastroenterol
; 23(1): 81, 2023 Mar 23.
Article
en En
| MEDLINE
| ID: mdl-36949385
ABSTRACT
BACKGROUND:
The impact of pre-existing comorbidities on acute pancreatitis (AP) mortality is not clearly defined. Our study aims to determine the trend in AP hospital mortality and the role of comorbidities as a predictor of hospital mortality.METHODS:
We analyzed patients aged ≥ 18 years hospitalized with AP diagnosis between 2016 and 2019. The data have been extracted from the Spanish National Hospital Discharge Database of the Spanish Ministry of Health. We performed a univariate and multivariable analysis of the association of age, sex, and comorbidities with hospital mortality in patients with AP. The role of the Charlson and Elixhauser comorbidity indices as predictors of mortality was evaluated.RESULTS:
A total of 110,021 patients diagnosed with AP were hospitalized during the analyzed period. Hospital mortality was 3.8%, with a progressive decrease observed in the years evaluated. In multivariable analysis, age ≥ 65 years (OR 4.11, p < 0.001), heart disease (OR 1.73, p < 0.001), renal disease (OR 1.99, p < 0.001), moderate-severe liver disease (OR 2.86, p < 0.001), peripheral vascular disease (OR 1.43, p < 0.001), and cerebrovascular disease (OR 1.63, p < 0.001) were independent risk factors for mortality. The Charlson > 1.5 (OR 2.03, p < 0.001) and Elixhauser > 1.5 (OR 2.71, p < 0.001) comorbidity indices were also independently associated with mortality, and ROC curve analysis showed that they are useful for predicting hospital mortality.CONCLUSIONS:
Advanced age, heart disease, renal disease, moderate-severe liver disease, peripheral vascular disease, and cerebrovascular disease before admission were independently associated with hospital mortality. The Charlson and Elixhauser comorbidity indices are useful for predicting hospital mortality in AP patients.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pancreatitis
/
Mortalidad Hospitalaria
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Humans
Idioma:
En
Revista:
BMC Gastroenterol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
España