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Histological endometrial dating: a reliable tool for personalized frozen-thawed embryo transfer in patients with repeated implantation failure in natural cycles.
Li, Yuan; Wen, Quan; Hu, Jing; Liao, Jingnan; Fan, Xiangxiu; Chen, Huijun; Zhao, Qi; Lu, Guang-Xiu; Lin, Ge; Gong, Fei.
Afiliación
  • Li Y; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China.
  • Wen Q; NHC Key Laboratory of Human Reproductive and Stem Cell Engineering, Changsha, China.
  • Hu J; NHC Key Laboratory of Human Reproductive and Stem Cell Engineering, Changsha, China.
  • Liao J; Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.
  • Fan X; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China.
  • Chen H; NHC Key Laboratory of Human Reproductive and Stem Cell Engineering, Changsha, China.
  • Zhao Q; NHC Key Laboratory of Human Reproductive and Stem Cell Engineering, Changsha, China.
  • Lu GX; Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.
  • Lin G; NHC Key Laboratory of Human Reproductive and Stem Cell Engineering, Changsha, China.
  • Gong F; Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.
BMC Pregnancy Childbirth ; 23(1): 199, 2023 Mar 22.
Article en En | MEDLINE | ID: mdl-36949405
OBJECTIVE: To evaluate the clinical availability and stability of histological endometrial dating as a tool for personalized frozen-thawed embryo transfer (pFET) in patients with repeated implantation failure (RIF) in natural cycles. METHODS: A total of 1245 RIF patients were recruited to the present study. All of the patients received an endometrial dating evaluation on day 7 post-ovulation (PO + 7) to guide their first pFET. The second and third pFETs were executed according to histological examination (again employing biopsy) or by reference to previous results. Subsequent pregnancy outcomes for all of the cycles were ultimately tracked. RESULTS: The out-of-phase rate for RIF patients was 32.4% (404/1245) and the expected dating rate (the probability of the expected endometrial dating aligning with repeat biopsy) for endometrial dating reevaluation was as high as 94.3% (50/53). The clinical pregnancy rates of first, second, and third pFETs were 65.3%, 50.0%, and 44.4%, respectively; and the cumulative clinical pregnancy rate attained 74.9% after three transfers. Endometrial dating reevaluations met expectations with more than a 2-year duration in three cases and elicited favorable clinical outcomes. CONCLUSION: We validated the relatively high stability of the histological endometrial dating platform-including the out-of-phase rate and the expected dating rate of reevaluation in patients with RIF-by expanding the sample size. The pFET, based on histological endometrial dating, was of acceptable clinical value and was worthy of promotion in patients with unexplained RIF.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Implantación del Embrión / Transferencia de Embrión Tipo de estudio: Observational_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: BMC Pregnancy Childbirth Asunto de la revista: OBSTETRICIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Implantación del Embrión / Transferencia de Embrión Tipo de estudio: Observational_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: BMC Pregnancy Childbirth Asunto de la revista: OBSTETRICIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido