Immune gene patterns and characterization of the tumor immune microenvironment associated with cancer immunotherapy efficacy.

Lin, Lili; Zhang, Wenda; Chen, Yongjian; Ren, Wei; Zhao, Jianli; Ouyang, Wenhao; He, Zifan; Su, Weifeng; Yao, Herui; Yu, Yunfang

Lin, Lili; Zhang, Wenda; Chen, Yongjian; Ren, Wei; Zhao, Jianli; Ouyang, Wenhao; He, Zifan; Su, Weifeng; Yao, Herui; Yu, Yunfang.

Afiliación

Lin L; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Medical Oncology, Breast Tumor Centre, Phase I Clinical Trial Centre, Medical Research Center, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
Zhang W; Department of Oncology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Chen Y; Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Ren W; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Medical Oncology, Breast Tumor Centre, Phase I Clinical Trial Centre, Medical Research Center, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
Zhao J; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Medical Oncology, Breast Tumor Centre, Phase I Clinical Trial Centre, Medical Research Center, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
Ouyang W; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Medical Oncology, Breast Tumor Centre, Phase I Clinical Trial Centre, Medical Research Center, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
He Z; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Medical Oncology, Breast Tumor Centre, Phase I Clinical Trial Centre, Medical Research Center, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
Su W; Division of Science and Technology, Beijing Normal University-Hong Kong Baptist University United International College, Hong Kong Baptist University, Zhuhai, China.
Yao H; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Medical Oncology, Breast Tumor Centre, Phase I Clinical Trial Centre, Medical Research Center, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
Yu Y; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Medical Oncology, Breast Tumor Centre, Phase I Clinical Trial Centre, Medical Research Center, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.

Heliyon ; 9(3): e14450, 2023 Mar.

Article en En | MEDLINE | ID: mdl-36950600

Palabras clave

AUC, Area under the curve; CIs, Confidence intervals; CTL, Cytotoxic T-lymphocyte infiltration; Cancer; GEO, Gene Expression Omnibus; GO, Gene Ontology; GSEA, Gene set enrichment analysis; GSVA, Gene set variation analysis; HLAs, Human leukocyte antigens; HRs, Hazard ratios; Immunotherapy; KEGG, Kyoto Encyclopedia of Genes and Genomes; LASSO, Penalized logistic least absolute shrinkage and selector operation; Machine learning; NSCLC, Non-small cell lung cancer; OS, Overall survival; PCA, Principal componentanalysis; PD-L1, Programmed death ligand-1; PFS, Profession-free survival; RNA-seq, Transcriptome RNA sequencing; ROC, receiver operating characteristic curves; TCGA, The Cancer Genome Atlas; TMB, Tumor mutation burden; TME, Tumor immunemicroenvironment; Tumor immune microenvironment; WGCNA, Weighted gene co-expression network analysis; lncRNA, Long non-coding RNA

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Heliyon Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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