A ciprofloxacin derivative with four mechanisms of action overcomes paclitaxel resistance in p53-mutant and MDR1 gene-expressing type II human endometrial cancer.

Alhaj-Suliman, Suhaila O; Naguib, Youssef W; Wafa, Emad I; Saha, Sanjib; Ebeid, Kareem; Meng, Xiangbing; Mohammed, Hamada H; Abuo-Rahma, Gamal El-Din A; Yang, Shujie; Salem, Aliasger K

Alhaj-Suliman, Suhaila O; Naguib, Youssef W; Wafa, Emad I; Saha, Sanjib; Ebeid, Kareem; Meng, Xiangbing; Mohammed, Hamada H; Abuo-Rahma, Gamal El-Din A; Yang, Shujie; Salem, Aliasger K.

Afiliación

Alhaj-Suliman SO; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa, IA, 52242, United States.
Naguib YW; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa, IA, 52242, United States; Departments of Pharmaceutics and Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Wafa EI; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa, IA, 52242, United States.
Saha S; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa, IA, 52242, United States.
Ebeid K; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa, IA, 52242, United States; Departments of Pharmaceutics and Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Meng X; Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, United States.
Mohammed HH; Departments of Pharmaceutics and Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Abuo-Rahma GEA; Departments of Pharmaceutics and Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Yang S; Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, United States.
Salem AK; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa, IA, 52242, United States. Electronic address: aliasger-salem@uiowa.edu.

Biomaterials ; 296: 122093, 2023 05.

Article en En | MEDLINE | ID: mdl-36965280

Asunto(s)

Antineoplásicos; Neoplasias Endometriales; Femenino; Humanos; Paclitaxel/farmacología; Paclitaxel/uso terapéutico; Proteína p53 Supresora de Tumor/genética; Proteína p53 Supresora de Tumor/metabolismo; Línea Celular Tumoral; Antineoplásicos/farmacología; Neoplasias Endometriales/tratamiento farmacológico; Neoplasias Endometriales/genética; Neoplasias Endometriales/metabolismo; Resistencia a Antineoplásicos/genética

Palabras clave

Drug accumulation; Drug resistance; MDR1 and p53 genes; Microtubules; Molecular combinatorial therapy; Topoisomerases

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Antineoplásicos Límite: Female / Humans Idioma: En Revista: Biomaterials Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

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