[Prevalence of torque teno mini virus (TTMV) and epstein-barr virus (EBV) in gingival tissues in 80 patients with periodontitis].

PURPOSE: To study the prevalence of torque teno mini virus (TTMV) and epstein-barr virus(EBV) in patients with periodontitis. METHODS: Gingival tissue samples were collected from 80 patients with periodontitis and 40 periodontal healthy volunteers. The presence of EBV and TTMV-222 were detected by nested PCR, and the virus loads were detected by real-time PCR. Statistical analysis was performed by SPSS 16.0 software package. RESULTS: The detection rates and virus loads of EBV and TTMV-222 in periodontitis group were significantly higher than those in periodontal health group (P＜0.05), and the detection rate of TTMV-222 in EBV positive group was significantly higher than that in EBV negative group (P＜0.01). There was a positive correlation between EBV and TTMV-222 in gingival tissues(P＜0.01). CONCLUSIONS: TTMV infection and co-infection of EBV and TTMV may be related to periodontal disease, but the pathogenic mechanism of the interaction between the two viruses needs further studies.