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Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Kschonsak, Marc; Jao, Christine C; Arthur, Christopher P; Rohou, Alexis L; Bergeron, Philippe; Ortwine, Daniel F; McKerrall, Steven J; Hackos, David H; Deng, Lunbin; Chen, Jun; Li, Tianbo; Dragovich, Peter S; Volgraf, Matthew; Wright, Matthew R; Payandeh, Jian; Ciferri, Claudio; Tellis, John C.
Afiliación
  • Kschonsak M; Genentech Inc, Structural Biology, South San Francisco, United States.
  • Jao CC; Genentech Inc, Structural Biology, South San Francisco, United States.
  • Arthur CP; Genentech Inc, Structural Biology, South San Francisco, United States.
  • Rohou AL; Genentech Inc, Structural Biology, South San Francisco, United States.
  • Bergeron P; Genentech Inc, Discovery Chemistry, South San Francisco, United States.
  • Ortwine DF; Genentech Inc, Discovery Chemistry, South San Francisco, United States.
  • McKerrall SJ; Genentech Inc, Discovery Chemistry, South San Francisco, United States.
  • Hackos DH; Genentech Inc, Neuroscience, South San Francisco, United States.
  • Deng L; Genentech Inc, Neuroscience, South San Francisco, United States.
  • Chen J; Genentech Inc, Biochemical and Cellular Pharmacology, South San Francisco, United States.
  • Li T; Genentech Inc, Biochemical and Cellular Pharmacology, South San Francisco, United States.
  • Dragovich PS; Genentech Inc, Discovery Chemistry, South San Francisco, United States.
  • Volgraf M; Genentech Inc, Discovery Chemistry, South San Francisco, United States.
  • Wright MR; Genentech Inc, Drug Metabolism and Pharmacokinetics, South San Francisco, United States.
  • Payandeh J; Genentech Inc, Structural Biology, South San Francisco, United States.
  • Ciferri C; Genentech Inc, Structural Biology, South San Francisco, United States.
  • Tellis JC; Genentech Inc, Discovery Chemistry, South San Francisco, United States.
Elife ; 122023 03 28.
Article en En | MEDLINE | ID: mdl-36975198
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microscopía por Crioelectrón Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Elife Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microscopía por Crioelectrón Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Elife Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido