Genotoxic activity of some water-soluble derivatives of 5-methoxypsoralen and 8-methoxypsoralen.
Carcinogenesis
; 7(4): 605-9, 1986 Apr.
Article
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| MEDLINE
| ID: mdl-3698192
ABSTRACT
This paper shows some results obtained by assaying the genotoxic activity on procaryotic and eucaryotic cells of some water-soluble psoralen derivatives. In particular, six newly synthesized derivatives of 5-methoxypsoralen (5-MOP) and of 8-methoxypsoralen (8-MOP) were tested; in previous studies they showed a strong anti-proliferative activity and a slight phototoxic effect; moreover, in view of a clinical use in the therapy of hyperproliferative skin diseases, these drugs should be less toxic than their parent compounds because of their good water solubility which could lead to a more efficient absorption and excretion. All the compounds tested here have shown genotoxic activity on both procaryotic and eucaryotic systems however, on the procaryotic cells the water-soluble derivatives were less genotoxic than their respective parent compounds 5-MOP and 8-MOP. Quite different results were obtained on V79 Chinese hamster cells, showing that, in general, the 8-methoxy-derivatives are more mutagenic than the methoxy-ones, although the 5-MOP itself was shown to be highly genotoxic in this system. This fact confirms that a conclusive estimate of the genotoxic risk related to the use of new drugs cannot be drawn from the results obtained on a single biological system.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Metoxaleno
Límite:
Animals
Idioma:
En
Revista:
Carcinogenesis
Año:
1986
Tipo del documento:
Article