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Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae).
Amang À Ngnoung, Gabrielle Ange; Sidjui, Lazare S; Leutcha, Peron B; Nganso Ditchou, Yves O; Tchokouaha, Lauve R Y; Herbette, Gaëtan; Baghdikian, Beatrice; Kowa, Theodora K; Soh, Desire; Kemzeu, Raoul; Poka, Madan; Demana, Patrick H; Siwe Noundou, Xavier; Tchinda, Alembert T; Fekam Boyom, Fabrice; Lannang, Alain M; Nyassé, Barthélemy.
Afiliación
  • Amang À Ngnoung GA; Department of Chemistry, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon.
  • Sidjui LS; Laboratory of Phytochemistry, Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaoundé P.O. Box 13033, Cameroon.
  • Leutcha PB; Laboratory of Phytochemistry, Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaoundé P.O. Box 13033, Cameroon.
  • Nganso Ditchou YO; Bioorganic and Medicinal Chemistry Laboratory, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé P.O. Box 812, Cameroon.
  • Tchokouaha LRY; Department of Chemistry, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon.
  • Herbette G; Natural Product and Environmental Chemistry Group (NAPEC), Department of Chemistry, Higher Teachers' Training College, University of Maroua, Maroua P.O. Box 55, Cameroon.
  • Baghdikian B; Department of Chemistry, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon.
  • Kowa TK; Laboratory of Medicinal Chemistry & Pharmacognosy, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé P.O. Box 812, Cameroon.
  • Soh D; Laboratory of Pharmacology and Drugs Discovery, IMPM, Yaoundé P.O. Box 13033, Cameroon.
  • Kemzeu R; Aix-Marseille Univ, CNRS, Centrale Marseille, FSCM, Spectropole, Campus de St Jérôme-Service 511, 13397 Marseille, France.
  • Poka M; Aix Marseille Univ, CNRS 7263, IRD 237, Avignon Université, IMBE, 27 Blvd Jean Moulin, Service of Pharmacognosy, Faculty of Pharmacy, 13385 Marseille, France.
  • Demana PH; Laboratory of Phytochemistry, Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaoundé P.O. Box 13033, Cameroon.
  • Siwe Noundou X; Laboratory of Medicinal Chemistry & Pharmacognosy, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé P.O. Box 812, Cameroon.
  • Tchinda AT; Department of Chemistry, Higher Teacher Training College Bambili, The University of Bamenda, Bambili, Bamenda P.O. Box 39, Cameroon.
  • Fekam Boyom F; Antimicrobial and Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon.
  • Lannang AM; Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
  • Nyassé B; Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Molecules ; 28(6)2023 Mar 17.
Article en En | MEDLINE | ID: mdl-36985700
ABSTRACT
Antrocaryon klaineanum is traditionally used for the treatment of back pain, malaria, female sterility, chlamydiae infections, liver diseases, wounds, and hemorrhoid. This work aimed at investigating the bioactive compounds with antileishmanial and antiplasmodial activities from A. klaineanum. An unreported glucocerebroside antroklaicerebroside (1) together with five known compounds (2-6) were isolated from the root barks of Antrocaryon klaineanum using chromatographic techniques. The NMR, MS, and IR spectroscopic data in association with previous literature were used for the characterization of all the isolated compounds. Compounds 1-4 are reported for the first time from A. klaineanum. The methanol crude extract (AK-MeOH), the n-hexane fraction (AK-Hex), the dichloromethane fraction (AK-DCM), the ethyl acetate fraction (AK-EtOAc), and compounds 1-6 were all evaluated for their antiparasitic effects against Plasmodium falciparum strains susceptible to chloroquine (3D7), resistant to chloroquine (Dd2), and promastigotes of Leishmania donovani (MHOM/SD/62/1S). The AK-Hex, AK-EtOAc, AK-MeOH, and compound 2 were strongly active against Dd2 strain with IC50 ranging from 2.78 ± 0.06 to 9.30 ± 0.29 µg/mL. Particularly, AK-MeOH was the most active-more than the reference drugs used-with an IC50 of 2.78 ± 0.06 µg/mL. The AK-EtOAc as well as all the tested compounds showed strong antileishmanial activities with IC50 ranging from 4.80 ± 0.13 to 9.14 ± 0.96 µg/mL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anacardiaceae / Antimaláricos / Antiprotozoarios Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Camerún
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anacardiaceae / Antimaláricos / Antiprotozoarios Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Camerún