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SARS-CoV-2 RNA Detected in Vitreous Samples Obtained at Autopsy.
Tieger, Marisa; Das Adhikari, Upasana; Mukai, Shizuo; Farcasnu, Mara; Stone, James R; Eliott, Dean; Kim, Leo A; Kwon, Douglas S; Rossin, Elizabeth J.
Afiliación
  • Tieger M; Harvard Medical School Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA, USA.
  • Das Adhikari U; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
  • Mukai S; Harvard Medical School Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA, USA.
  • Farcasnu M; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
  • Stone JR; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  • Eliott D; Harvard Medical School, Boston, MA, USA.
  • Kim LA; Harvard Medical School Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA, USA.
  • Kwon DS; Harvard Medical School Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA, USA.
  • Rossin EJ; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
J Vitreoretin Dis ; 6(3): 183-187, 2022.
Article en En | MEDLINE | ID: mdl-37008551
ABSTRACT

Purpose:

This work aims to examine the vitreous of autopsy patients with COVID-19 for the presence of SARS-CoV-2 RNA.

Methods:

Four deceased patients with COVID-19 had an autopsy at Massachusetts General Hospital. Two control specimens were obtained from patients undergoing retinal detachment repair with negative preoperative polymerase chain reaction (PCR) testing for SARS-CoV-2 RNA. Vitreous specimens were obtained from autopsy patients with COVID-19 after povidone was placed on the ocular surface to decrease the risk of contamination of the vitreous specimen. SARS-CoV-2 RNA for gene N (nucleocapsid) was tested using reverse transcription-PCR.

Results:

SARS-CoV-2 RNA was detected in the vitreous of 2 of 4 autopsy patients who died from complications of COVID-19.

Conclusions:

SARS-CoV-2 RNA can penetrate into the vitreous of systemically infected patients, which might present risks to operating room personnel during ophthalmic surgical procedures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Vitreoretin Dis Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Vitreoretin Dis Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos