Pathologically mislocalised TDP-43 in upper motor neurons causes a die-forward spread of ALS-like pathogenic changes throughout the mouse corticomotor system.

Reale, Laura A; Dyer, Marcus S; Perry, Sharn E; Young, Kaylene M; Dickson, Tracey C; Woodhouse, Adele; Blizzard, Catherine A

Reale, Laura A; Dyer, Marcus S; Perry, Sharn E; Young, Kaylene M; Dickson, Tracey C; Woodhouse, Adele; Blizzard, Catherine A.

Afiliación

Reale LA; Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Dyer MS; Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Perry SE; The Wicking Dementia Centre, University of Tasmania, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Young KM; Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Dickson TC; Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Woodhouse A; The Wicking Dementia Centre, University of Tasmania, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Blizzard CA; Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, TAS 7000, Australia; Tasmanian School of Medicine, University of Tasmania, 17 Liverpool Street, Hobart, TAS 7000, Australia. Electronic address: Catherine.Blizzard@utas.edu.au.

Prog Neurobiol ; 226: 102449, 2023 Jul.

Article en En | MEDLINE | ID: mdl-37011806

Asunto(s)

Esclerosis Amiotrófica Lateral; Ratones; Animales; Esclerosis Amiotrófica Lateral/genética; Neuronas Motoras/metabolismo; Neuronas Motoras/patología; Médula Espinal/metabolismo; Proteínas de Unión al ADN/metabolismo

Palabras clave

Amyotrophic lateral sclerosis; Cortical hyperexcitability; Corticomotor system; Pre-synaptic protein; Spinal cord circuitry; TDP-43

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Amiotrófica Lateral Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Prog Neurobiol Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido

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