The role of GDF11 during inflammation - An overview.
Life Sci
; 322: 121650, 2023 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-37011872
ABSTRACT
GDF11 (Growth differentiation factor 11) is a newly discovered member of family of transforming growth factors-ß. Its crucial role was confirmed in physiology, i.e. embryogenesis due to its involvement in bone formation, skeletogenesis and it is essential to stating skeletal pattern. GDF11 is described as a rejuvenating and anti-aging molecule, that could even restore functions. Beside embryogenesis, GDF11 participates in the process of inflammation and carcinogenesis. An anti-inflammatory effect of GDF11 was found in experimental colitis, psoriasis and arthritis. Current data regarding liver fibrosis and renal injury indicate that GDF11 may act as pro-inflammatory agent. In this review, we describe its involvement in regulation of acute and chronic inflammatory disorders.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Psoriasis
/
Factores de Diferenciación de Crecimiento
Límite:
Humans
Idioma:
En
Revista:
Life Sci
Año:
2023
Tipo del documento:
Article
País de afiliación:
Polonia