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Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus.
Zhao, Ling; Mühleisen, Thomas W; Pelzer, Dominique I; Burger, Bettina; Beins, Eva C; Forstner, Andreas J; Herms, Stefan; Hoffmann, Per; Amunts, Katrin; Palomero-Gallagher, Nicola; Cichon, Sven.
Afiliación
  • Zhao L; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany.
  • Mühleisen TW; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany; Cécile and Oskar Vogt Institute for Brain Research, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Germany; Department of Biomedicine, University Hospital Basel and University of
  • Pelzer DI; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany.
  • Burger B; Department of Biomedicine, University Hospital Basel and University of Basel, Switzerland.
  • Beins EC; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
  • Forstner AJ; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
  • Herms S; Department of Biomedicine, University Hospital Basel and University of Basel, Switzerland; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
  • Hoffmann P; Department of Biomedicine, University Hospital Basel and University of Basel, Switzerland; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
  • Amunts K; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany; Cécile and Oskar Vogt Institute for Brain Research, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Germany.
  • Palomero-Gallagher N; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany; Cécile and Oskar Vogt Institute for Brain Research, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Germany. Electronic address: n.palomero-gallagher@fz-juelich.de.
  • Cichon S; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany; Department of Biomedicine, University Hospital Basel and University of Basel, Switzerland; Institute of Medical Genetics and Pathology, University Hospital Basel, Switzerland. Electronic address: s.cichon@fz-juelich.de.
Neuroimage ; 273: 120095, 2023 06.
Article en En | MEDLINE | ID: mdl-37030412
Neurotransmitter receptors are key molecules in signal transmission, their alterations are associated with brain dysfunction. Relationships between receptors and their corresponding genes are poorly understood, especially in humans. We combined in vitro receptor autoradiography and RNA sequencing to quantify, in the same tissue samples (7 subjects), the densities of 14 receptors and expression levels of their corresponding 43 genes in the Cornu Ammonis (CA) and dentate gyrus (DG) of human hippocampus. Significant differences in receptor densities between both structures were found only for metabotropic receptors, whereas significant differences in RNA expression levels mostly pertained ionotropic receptors. Receptor fingerprints of CA and DG differ in shapes but have similar sizes; the opposite holds true for their "RNA fingerprints", which represent the expression levels of multiple genes in a single area. In addition, the correlation coefficients between receptor densities and corresponding gene expression levels vary widely and the mean correlation strength was weak-to-moderate. Our results suggest that receptor densities are not only controlled by corresponding RNA expression levels, but also by multiple regionally specific post-translational factors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Neurotransmisores / Hipocampo Límite: Humans Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Neurotransmisores / Hipocampo Límite: Humans Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos