Equilibration time of haemoglobin concentration after packed red blood cell transfusion in children seen in the emergency unit of a tertiary hospital in Southeast, Nigeria.

ABSTRACT

Blood transfusion is an important treatment modality for severe anaemia. Monitoring post-transfusion haemoglobin (Hb) concentration helps the clinician in assessing the success of blood transfusion. Previous authors have reported different timings for post-transfusion equilibration using varied time intervals for post-transfusion Hb concentration assessment. This study was therefore aimed at determining the appropriate time to assess Hb concentration after packed red blood cell (pRBC) transfusion in children using 5 different time intervals. It was a longitudinal observational study carried out in a tertiary care hospital in Southeast, Nigeria and involved 108 children aged 1-10 years without active bleeding or significant haemolysis that were transfused with pRBC. The Hb concentration was measured using a portable haemoglobinometer just before the blood transfusion and after the blood transfusion at 1, 6, 12, 24, and 48th-hour. The 1-hour (6.8 ± 1.5 g/dl) post-transfusion Hb concentration was significantly different (p 0.001) from the 6th-hour (10.2 ± 1.5 g/dl), but no further significant (p > 0.05) changes occurred after the 6th-hour till the 48th-hour. This finding suggests that equilibration of Hb concentration had occurred by the 6th hour after blood transfusion. This study, therefore, recommends that Hb concentration assessment in children without ongoing bleeding or haemolysis can be done at the 6th hour after pRBC transfusion.