Quantification of cardiac iron in patients with thalassemia with 3-T MRI calibrated by 1.5-T MRI.
Acta Radiol
; 64(6): 2096-2103, 2023 Jun.
Article
en En
| MEDLINE
| ID: mdl-37032518
BACKGROUND: Due to the small sample size of many studies, it remained unclear what standardized reference range the T2* cutoff at 3â
T would be used to assess the severity of cardiac iron load. In addition, the number of patients with moderate to severe cardiac iron load was small in some studies, especially the sample of patients with severe cardiac iron load. PURPOSE: To explore the feasibility, reproducibility, and reliability of using T2* values in quantifying cardiac iron load in patients with thalassemia at 3â
T. MATERIAL AND METHODS: A total of 122 patients with thalassemia underwent cardiac T2* imaging at both 1.5â
T and 3â
T. Cardiac R2* (1000/T2*) values of the 100 patients at 3â
T were fitted against the values at 1.5â
T using linear regression and the prediction equation was derived. The remaining 22 cases were used to test the prediction accuracy of the equation. RESULTS: The combined R2* values exhibited a strong linear relationship between 1.5â
T and 3â
T (r = 0.830ï¼P<0.001). At the center, it had a slope of 1.348 and an intercept of 37.279. According to the equation, the truncated T2* values of cardiac iron overload and cardiac heavy iron overload at 3â
T were <10â
ms and <6â
ms, respectively. The two truncated T2* values were used to diagnose different levels of cardiac iron overloaded of 22 patients at 3â
T; the accuracy rates were 95.5% and 100.0%, respectively. CONCLUSION: T2* quantification of cardiac iron load at 3â
T MRI resulted to be feasible, reproducible, and reliable.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Talasemia
/
Sobrecarga de Hierro
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Acta Radiol
Año:
2023
Tipo del documento:
Article
Pais de publicación:
Reino Unido