Acrylamide induces the activation of BV2 microglial cells through TLR2/4-mediated LRRK2-NFATc2 signaling cascade.

Yan, Xiaoyu; Li, Qiuju; Wu, Shuangyue; Liang, Jie; Li, Yuanyuan; Zhang, Tingting; Chen, Dayi; Pan, Xiaoqi

Yan, Xiaoyu; Li, Qiuju; Wu, Shuangyue; Liang, Jie; Li, Yuanyuan; Zhang, Tingting; Chen, Dayi; Pan, Xiaoqi.

Afiliación

Yan X; School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Li Q; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Sichuan, 610075, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Wu S; School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Liang J; School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Li Y; School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Zhang T; School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Chen D; School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China. Electronic address: chendayi0523@sina.com.
Pan X; School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Sichuan, 610075, China. Electronic address: panxiaoqi1104@cdutcm.edu.cn.

Food Chem Toxicol ; 176: 113775, 2023 Jun.

Article en En | MEDLINE | ID: mdl-37037409

Asunto(s)

Microglía; Receptor Toll-Like 2; Receptor Toll-Like 2/genética; Receptor Toll-Like 2/metabolismo; Factores de Transcripción NFATC/genética; Factores de Transcripción NFATC/metabolismo; Acrilamida/metabolismo; Receptor Toll-Like 4/metabolismo; Interleucina-6/metabolismo; Línea Celular; Lipopolisacáridos/farmacología; Lipopolisacáridos/metabolismo; FN-kappa B/metabolismo

Palabras clave

Acrylamide; BV2 microglial cells; Gallic acid; LRKK2-NFATc2 signaling cascade; TLR2/TLR4

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microglía / Receptor Toll-Like 2 Idioma: En Revista: Food Chem Toxicol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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