Gut content microbiota dysbiosis and dysregulated lipid metabolism in diarrhea caused by high-fat diet in a fatigued state.
Food Funct
; 14(8): 3880-3892, 2023 Apr 24.
Article
en En
| MEDLINE
| ID: mdl-37038883
ABSTRACT
Previous evidence has indicated that fatigue and a high-fat diet (HFD) cause the adaptive organism responses to be dysregulated, resulting in gastrointestinal (GI) disorders. Generally, gut microbiota plays a crucial role in GI disorders. However, the impact of fatigue and an HFD on the microbiome and GI disorders remains to be fully explored. Mice were randomly divided into the control group (CCN), standing group (CSD), lard group (CLD), and standing + lard group (CSLD). Mice in the CSD and CSLD groups stood on the multiple-platform apparatus for four h per day for 14 consecutive days. From the eighth day, mice in the CLD and CSLD groups were fed intragastric lard and the CCN and CSD groups were subjected to intragastric treatment with sterile water, 0.4 mL per each, twice a day for seven days. Subsequently, we analyzed the characteristics and interaction relationship of gut content microbiota (GCM), brain-gut peptides, and lipid metabolism. Mice in the CSLD group were in a fatigued state and had diarrhea. Compared with the CCN group, high-density lipoproteins were significantly lower, and the lipid droplet optical density value was substantially higher in the CSLD group (p < 0.05). CSLD mice presented significant structural damage to the small intestine and considerably higher ß-endorphin, cholecystokinin, and somatostatin (p < 0.05). Bacillus, Gemella, and Bosea were the characteristic bacteria of the CSLD group, and Gemella was significantly negatively correlated with total cholesterol. Gut microbiota dysbiosis and dysregulated lipid metabolism contribute to diarrhea caused by an HFD diet in a fatigued state.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dieta Alta en Grasa
/
Microbioma Gastrointestinal
Límite:
Animals
Idioma:
En
Revista:
Food Funct
Año:
2023
Tipo del documento:
Article
País de afiliación:
China