P2 receptor-mediated signaling in the physiological and pathological brain: From development to aging and disease.
Neuropharmacology
; 233: 109541, 2023 08 01.
Article
en En
| MEDLINE
| ID: mdl-37062423
ABSTRACT
The purinergic pathway mediates both pro-inflammatory and anti-inflammatory responses, whereas the breakdown of adenosine triphosphate (ATP) is in a critical equilibrium. Under physiological conditions, extracellular ATP is maintained at a nanomolar concentration. Whether released into the medium following tissue damage, inflammation, or hypoxia, ATP is considered a clear indicator of cell damage and a marker of pathological conditions. In this overview, we provide an update on the participation of P2 receptor-mediated purinergic signaling in normal and pathological brain development, with special emphasis on neurodevelopmental psychiatric disorders. Since purinergic signaling is ubiquitous, it is not surprising that it plays a prominent role in developmental processes and pathological alterations. The main aim of this review is to conceptualize the time-dependent dynamic changes in the participation of different players in the purinome in shaping the normal and aberrant developmental patterns and diseases of the central nervous system over one's lifespan. This article is part of the Special Issue on "Purinergic Signaling 50 years".
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores Purinérgicos P2
Límite:
Humans
Idioma:
En
Revista:
Neuropharmacology
Año:
2023
Tipo del documento:
Article
País de afiliación:
Hungria