Regio- and Diastereoselective Radical Hydroboration of N-Aryl Enamine Carboxylates for the Synthesis of anti-ß-Amino Organoborons.
Org Lett
; 25(16): 2852-2856, 2023 Apr 28.
Article
en En
| MEDLINE
| ID: mdl-37071656
ABSTRACT
The regio- and diastereoselective hydroboration of N-aryl enamine carboxylates was achieved by dichloro-substituted N-heterocyclic carbene (NHC)-boryl radical to access the valuable anti-ß-amino boron skeleton. Excellent diastereoselectivity (>955 dr) was obtained using dichloro-NHC-BH3 (boryl radical precursor) and the thiol catalyst. Broad substrate scope and good functional group tolerance were demonstrated. Further transformation of the product to amino alcohol exemplified the synthetic utility of this reaction.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2023
Tipo del documento:
Article
País de afiliación:
China