Application of ultrasound attenuation imaging and shear wave elastography in the diagnosis of metabolic fatty liver disease.

This study aimed to investigate the application of ultrasound attenuation imaging (ATI) and shear wave elastography (SWE) in the examination of patients with metabolism-related fatty liver disease (MAFLD). A total of 210 patients were retrospectively selected and divided into MAFLD group (n=84) and no MAFLD group (n=126). ROC curve was used to analyze the diagnostic efficacy of ATI value and SWE value for MAFLD. The MAFLD groups were divided into mild group (n=39), moderate group (n=28) and severe group (n=17). Spearman correlation was used to analyze the relationship between ATI values, SWE values and the severity of MAFLD. Waist circumference, BMI, ALT, AST, TG, CHOL, ATI and SWE in MAFLD group were higher than those in non-MAFLD group (P<0.05). ROC analysis showed that the AUC of ATI value in the diagnosis of MAFLD was 0.837 and the sensitivity, specificity and cutoff values were 83.46%, 70.35% and 0.63 dB/cm/MHZ. Waist circumference and BMI were significantly lower in the mild MAFLD group than in the moderate MAFLD group (P<0.05) and ALT, AST, TG, CHOL, ATI and SWE levels gradually increased with the severity of MAFLD (P<0.05). Correlation analysis showed that ATI was positively correlated with MAFLD severity (r=0.553, P<0.001, 95% CI=0.384~0.686) and SWE was significantly positively correlated with MAFLD severity (r=0.606, P<0.001, 95% CI=0.450~0.726). Both ATI and SWE are effective in the diagnosis and evaluation of MAFLD, but ATI is more effective in the diagnosis and SWE.