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A novel role of DOT1L in kidney diseases.
Wei, Wei; Zhao, Yibo; Chai, Yanfen; Shou, Songtao; Jin, Heng.
Afiliación
  • Wei W; Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China.
  • Zhao Y; Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China.
  • Chai Y; Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China.
  • Shou S; Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China. stshou66@sina.com.
  • Jin H; Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China. hengjin@tmu.edu.cn.
Mol Biol Rep ; 50(6): 5415-5423, 2023 Jun.
Article en En | MEDLINE | ID: mdl-37085741
ABSTRACT

BACKGROUND:

We systematically summarized the structure and biological function of DOT1L in detail, and further discussed the role of DOT1L in kidney diseases through different mechanisms. METHODS AND

RESULTS:

We first described the role of DOT1L in various kidney diseases including AKI, CKD, DN and kidney tumor diseases.

CONCLUSIONS:

A better understanding of DOT1L as a histone methylase based on characteristics of regulating telomere silencing, transcriptional extension, DNA damage repair and cell cycle could lead to the development of new therapeutic targets for various kidney diseases, thereby improving the prognosis of kidney disease patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Renales / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Mol Biol Rep Año: 2023 Tipo del documento: Article
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Renales / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Mol Biol Rep Año: 2023 Tipo del documento: Article