A novel role of DOT1L in kidney diseases.
Mol Biol Rep
; 50(6): 5415-5423, 2023 Jun.
Article
en En
| MEDLINE
| ID: mdl-37085741
ABSTRACT
BACKGROUND:
We systematically summarized the structure and biological function of DOT1L in detail, and further discussed the role of DOT1L in kidney diseases through different mechanisms. METHODS ANDRESULTS:
We first described the role of DOT1L in various kidney diseases including AKI, CKD, DN and kidney tumor diseases.CONCLUSIONS:
A better understanding of DOT1L as a histone methylase based on characteristics of regulating telomere silencing, transcriptional extension, DNA damage repair and cell cycle could lead to the development of new therapeutic targets for various kidney diseases, thereby improving the prognosis of kidney disease patients.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Renales
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Mol Biol Rep
Año:
2023
Tipo del documento:
Article