Ferroptosis model system by the re-expression of BACH1.

Irikura, Riko; Nishizawa, Hironari; Nakajima, Kazuma; Yamanaka, Mie; Chen, Guan; Tanaka, Kozo; Onodera, Masafumi; Matsumoto, Mitsuyo; Igarashi, Kazuhiko

Irikura, Riko; Nishizawa, Hironari; Nakajima, Kazuma; Yamanaka, Mie; Chen, Guan; Tanaka, Kozo; Onodera, Masafumi; Matsumoto, Mitsuyo; Igarashi, Kazuhiko.

Afiliación

Irikura R; Department of Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Nishizawa H; Department of Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Nakajima K; Department of Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Yamanaka M; Department of Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Chen G; Gladstone Institute of Neurological Disease, Gladstone Institutes, 1650 Owens Street, San Francisco, CA 94158, USA.
Tanaka K; Department of Molecular Oncology, Institute of Development, Aging and Cancer (IDAC), Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Onodera M; Department of Molecular Oncology, Institute of Development, Aging and Cancer (IDAC), Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Matsumoto M; Gene & Cell Therapy Promotion Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.
Igarashi K; Department of Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

J Biochem ; 174(3): 239-252, 2023 Jul 31.

Article en En | MEDLINE | ID: mdl-37094356

Asunto(s)

Ferroptosis; Fibroblastos; Animales; Humanos; Ratones; Fibroblastos/metabolismo; Ferroptosis/genética; Fosfolípido Hidroperóxido Glutatión Peroxidasa/metabolismo; Hierro/metabolismo; Glutatión/metabolismo; Factores de Transcripción con Cremalleras de Leucina de Carácter Básico/genética; Factores de Transcripción con Cremalleras de Leucina de Carácter Básico/metabolismo

Palabras clave

BACH1 Abbreviations: AIFM2, apoptosis-inducing factor mitochondria-associated 2; ANOVA, analysis of variance; BACH1, BTB and CNC homology 1; Bach1−/− mice, Bach1 knockout mice; BTB, Broad complex, Tramtrack, Bric-a-brac domain; bZIP, basic leucine zipper; ChIP-seq, chromatin immunoprecipitation sequencing; CNC, Cap'n'Collar region; DAPI, 4',6-diamidino-2-phenylindole; DFX, deferasirox; DMSO, dimethyl sulfoxide; EMT, epithelialmesenchymal transition; Ferr-1, ferrostatin-1; FINs, ferroptosis inducers; FSP1, Ferroptosis suppressor protein 1; Fth1, ferritin heavy chain 1; Ftl, ferritin light chain; GCL, glutamate-cysteine ligase; Gclc, GCL catalytic subunit; Gclm, GCL modifier subunit; GEO, Gene Expression Omnibus; GPX4, glutathione peroxidase 4; GSH, glutathione; HO-1 (Hmox1), heme oxygenase 1; iMEFs, immortalized MEFs; KuO, Kusabira Orange; MAFK, musculoaponeurotic fibrosarcoma oncogene homolog bZIP transcription factor K; mBACH1, Bach1 gene of Mus musculus; 2-ME, 2-mercaptoethanol; MEFs, mouse embryonic fibroblasts; NRF2, nuclear factor-erythroid 2-related factor 2; NSA, necrosulfonamide; PDAC, pancreatic ductal adenocarcinoma; PI, Propidium iodide; Ptgs2, prostaglandin-endoperoxide synthase 2; RSL3, (1S,3R)-RSL3; Slc40a1, solute carrier family 40 member 1; Slc7a11, solute carrier family 7 member 11; TFRC, transferrin receptor 1; Z-VAD.FMK, Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone; extracellular signal; ferroptosis; fibroblasts; transcription

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibroblastos / Ferroptosis Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Biochem Año: 2023 Tipo del documento: Article País de afiliación: Japón

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