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Urine as matrix for analysis of neurofilament light chain is not suitable to distinguish frontotemporal dementia from psychiatric diseases.
van Engelen, Marie-Paule E; Heijst, Hans; Willemse, Eline A J; Oudega, Mardien L; Vermunt, Lisa; Scheltens, Philip; Vijverberg, Everard G B; Pijnenburg, Yolande A L; Teunissen, Charlotte E.
Afiliación
  • van Engelen ME; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Noord-Holland 1081 HZ, The Netherlands.
  • Heijst H; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Noord-Holland 1081 HV, The Netherlands.
  • Willemse EAJ; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV, Amsterdam, The Netherlands.
  • Oudega ML; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV, Amsterdam, The Netherlands.
  • Vermunt L; Department of Neurology, University Hospital Basel and University of Basel, 4031, Basel, Switzerland.
  • Scheltens P; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Noord-Holland 1081 HZ, The Netherlands.
  • Vijverberg EGB; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Noord-Holland 1081 HV, The Netherlands.
  • Pijnenburg YAL; GGZ inGeest Specialized Mental Health Care, Location De Nieuwe Valerius, Amsterdam, Noord-Holland 1070 BB, The Netherlands.
  • Teunissen CE; Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, Noord-Holland 1081 HV, The Netherlands.
Brain Commun ; 5(2): fcad120, 2023.
Article en En | MEDLINE | ID: mdl-37101834
ABSTRACT
The clinical overlap of frontotemporal dementia and primary psychiatric diseases hampers diagnostic distinction, leading to frequent misdiagnosis and diagnostic delay. Neurofilament light chain has shown great potential in CSF and blood for the distinction of frontotemporal dementia from primary psychiatric diseases. Measurement of neurofilament light chain in urine would be even more patient-friendly. We aimed to test the performance of neurofilament light chain urine measurements for diagnostics in frontotemporal dementia and to assess their correlation with serum levels. Fifty-five subjects (n = 19 frontotemporal dementia, n = 19 primary psychiatric diseases and n = 17 controls) were included with available paired urine and serum samples. All subjects underwent standardized extensive diagnostic assessment. Samples were analysed with the ultrasensitive single molecule array neurofilament light chain assay. Neurofilament light chain group comparisons were performed adjusted for age, sex and geriatric depression scale. In the majority of the cohort, neurofilament light chain concentrations were not detectable in urine (n = 6 samples above lower limit of detection (0.038 pg/ml) n = 5 frontotemporal dementia, n = 1 primary psychiatric disease). The frequency of a detectable neurofilament light chain level in urine in the frontotemporal dementia group did not differ from psychiatric disorders (Fisher Exact-test P = 0.180). In the individuals with detectable urine neurofilament light chain values, there was no correlation between the urine and serum neurofilament light chain levels. As expected, serum neurofilament light chain levels were higher in frontotemporal dementia compared to primary psychiatric diseases and controls (P < 0.001), adjusted for age, sex and geriatric depression scale. Receiver operating characteristic curve analysis of serum neurofilament light chain of frontotemporal dementia versus primary psychiatric diseases showed an area under the curve of 0.978 95% confidence interval 0.941-1.000, P < 0.001. Urine is not suitable as a matrix for neurofilament light chain analysis and serum neurofilament light chain is still the most patient-friendly matrix for differentiation between frontotemporal dementia and primary psychiatric diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Brain Commun Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Brain Commun Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos