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Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells.
Mattheisen, Jordan M; Limberakis, Chris; Ruggeri, Roger B; Dowling, Matthew S; Am Ende, Christopher W; Ceraudo, Emilie; Huber, Thomas; McClendon, Christopher L; Sakmar, Thomas P.
Afiliación
  • Mattheisen JM; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, New York 10065, United States.
  • Limberakis C; Tri-Institutional PhD Program in Chemical Biology, New York, New York 10065, United States.
  • Ruggeri RB; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.
  • Dowling MS; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.
  • Am Ende CW; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.
  • Ceraudo E; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.
  • Huber T; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, New York 10065, United States.
  • McClendon CL; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, New York 10065, United States.
  • Sakmar TP; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.
J Am Chem Soc ; 145(20): 11173-11184, 2023 05 24.
Article en En | MEDLINE | ID: mdl-37116188
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Acoplados a Proteínas G / Aminoácidos Idioma: En Revista: J Am Chem Soc Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Acoplados a Proteínas G / Aminoácidos Idioma: En Revista: J Am Chem Soc Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos