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Sex-Biased Expression Is Associated With Chromatin State in Drosophila melanogaster and Drosophila simulans.
Nanni, Adalena V; Martinez, Natalie; Graze, Rita; Morse, Alison; Newman, Jeremy R B; Jain, Vaibhav; Vlaho, Srna; Signor, Sarah; Nuzhdin, Sergey V; Renne, Rolf; McIntyre, Lauren M.
Afiliación
  • Nanni AV; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL.
  • Martinez N; University of Florida Genetics Institute, University of Florida, Gainesville, FL.
  • Graze R; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL.
  • Morse A; Department of Biological Sciences, Auburn University, Auburn, AL.
  • Newman JRB; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL.
  • Jain V; University of Florida Genetics Institute, University of Florida, Gainesville, FL.
  • Vlaho S; University of Florida Genetics Institute, University of Florida, Gainesville, FL.
  • Signor S; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL.
  • Nuzhdin SV; Department of Biological Sciences, University of Southern California, Los Angeles, CA.
  • Renne R; Department of Biological Sciences, North Dakota State University, Fargo, ND.
  • McIntyre LM; Department of Biological Sciences, University of Southern California, Los Angeles, CA.
Mol Biol Evol ; 40(5)2023 05 02.
Article en En | MEDLINE | ID: mdl-37116218
In Drosophila melanogaster and D. simulans head tissue, 60% of orthologous genes show evidence of sex-biased expression in at least one species. Of these, ∼39% (2,192) are conserved in direction. We hypothesize enrichment of open chromatin in the sex where we see expression bias and closed chromatin in the opposite sex. Male-biased orthologs are significantly enriched for H3K4me3 marks in males of both species (∼89% of male-biased orthologs vs. ∼76% of unbiased orthologs). Similarly, female-biased orthologs are significantly enriched for H3K4me3 marks in females of both species (∼90% of female-biased orthologs vs. ∼73% of unbiased orthologs). The sex-bias ratio in female-biased orthologs was similar in magnitude between the two species, regardless of the closed chromatin (H3K27me2me3) marks in males. However, in male-biased orthologs, the presence of H3K27me2me3 in both species significantly reduced the correlation between D. melanogaster sex-bias ratio and the D. simulans sex-bias ratio. Male-biased orthologs are enriched for evidence of positive selection in the D. melanogaster group. There are more male-biased genes than female-biased genes in both species. For orthologs with gains/losses of sex-bias between the two species, there is an excess of male-bias compared to female-bias, but there is no consistent pattern in the relationship between H3K4me3 or H3K27me2me3 chromatin marks and expression. These data suggest chromatin state is a component of the maintenance of sex-biased expression and divergence of sex-bias between species is reflected in the complexity of the chromatin status.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromatina / Drosophila melanogaster Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Mol Biol Evol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromatina / Drosophila melanogaster Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Mol Biol Evol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos