Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma.

Sgro, Agustin; Cursons, Joseph; Waryah, Charlene; Woodward, Eleanor A; Foroutan, Momeneh; Lyu, Ruqian; Yeoh, George C T; Leedman, Peter J; Blancafort, Pilar

Sgro, Agustin; Cursons, Joseph; Waryah, Charlene; Woodward, Eleanor A; Foroutan, Momeneh; Lyu, Ruqian; Yeoh, George C T; Leedman, Peter J; Blancafort, Pilar.

Afiliación

Sgro A; Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, Nedlands, Perth, WA, 6009, Australia.
Cursons J; Centre for Medical Research, The University of Western Australia, Perth, WA, 6009, Australia.
Waryah C; School of Human Sciences, The University of Western Australia, Crawley, Perth, WA, 6009, Australia.
Woodward EA; Biomedicine Discovery Institute and the Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia.
Foroutan M; Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, Nedlands, Perth, WA, 6009, Australia.
Lyu R; Centre for Medical Research, The University of Western Australia, Perth, WA, 6009, Australia.
Yeoh GCT; Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, Nedlands, Perth, WA, 6009, Australia.
Leedman PJ; Centre for Medical Research, The University of Western Australia, Perth, WA, 6009, Australia.
Blancafort P; Biomedicine Discovery Institute and the Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia.

Clin Epigenetics ; 15(1): 73, 2023 04 29.

Article en En | MEDLINE | ID: mdl-37120619

Asunto(s)

Carcinoma Hepatocelular; Neoplasias Hepáticas; Humanos; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/patología; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patología; Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas; Metilación de ADN; Epigénesis Genética; Genes Supresores de Tumor; Línea Celular Tumoral; Regulación Neoplásica de la Expresión Génica

Palabras clave

CRISPRa; Epigenetic drugs; Epigenetic editing toolbox; Genome multiplexing; Hepatocellular carcinoma; Precision medicine; Tumor suppressor genes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Clin Epigenetics Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania

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