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Use of the neutrophil-to-lymphocyte ratio and an oxygen requirement to predict disease severity in patients with COVID-19.
Ozawa, Takuya; Asakura, Takanori; Chubachi, Shotaro; Namkoong, Ho; Tanaka, Hiromu; Lee, Ko; Fukushima, Takahiro; Otake, Shiro; Nakagawara, Kensuke; Watase, Mayuko; Masaki, Katsunori; Kamata, Hirofumi; Ishii, Makoto; Hasegawa, Naoki; Harada, Norihiro; Ueda, Tetsuya; Ueda, Soichiro; Ishiguro, Takashi; Arimura, Ken; Saito, Fukuki; Yoshiyama, Takashi; Nakano, Yasushi; Mutoh, Yoshikazu; Suzuki, Yusuke; Edahiro, Ryuya; Murakami, Koji; Okada, Yukinori; Koike, Ryuji; Kitagawa, Yuko; Tokunaga, Katsushi; Kimura, Akinori; Imoto, Seiya; Miyano, Satoru; Ogawa, Seishi; Kanai, Takanori; Fukunaga, Koichi.
Afiliación
  • Ozawa T; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Asakura T; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan; Department of Respiratory Medicine, Kitasato University, Kitasato Institute Hospital, Tokyo, Japan; Department of Clinical Medicine (Laboratory of Bioregulatory Medicine), Kitasato
  • Chubachi S; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Namkoong H; Department of Infectious Diseases, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Tanaka H; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Lee K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Fukushima T; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Otake S; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Nakagawara K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Watase M; Department of Respiratory Medicine, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
  • Masaki K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Kamata H; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Ishii M; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Hasegawa N; Department of Infectious Diseases, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Harada N; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
  • Ueda T; Department of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
  • Ueda S; JCHO (Japan Community Health Care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.
  • Ishiguro T; Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
  • Arimura K; Department of Respiratory Medicine, Tokyo Women's Medical University, Tokyo, Japan.
  • Saito F; Department of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan.
  • Yoshiyama T; Fukujuji Hospital, Kiyose, Japan.
  • Nakano Y; Kawasaki Municipal Ida Hospital, Department of Internal Medicine, Kawasaki, Japan.
  • Mutoh Y; Department of Infectious Diseases, Tosei General Hospital, Seto, Japan.
  • Suzuki Y; Department of Respiratory Medicine, Kitasato University, Kitasato Institute Hospital, Tokyo, Japan; Department of Clinical Medicine (Laboratory of Bioregulatory Medicine), Kitasato University School of Pharmacy, Tokyo, Japan.
  • Edahiro R; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
  • Murakami K; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan; The Center for Infectious Disease Education and Re
  • Koike R; Medical Innovation Promotion Center, Tokyo Medical and Dental University, Tokyo, Japan.
  • Kitagawa Y; Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
  • Tokunaga K; Genome Medical Science Project (Toyama), National Center for Global Health and Medicine, Tokyo, Japan.
  • Kimura A; Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan.
  • Imoto S; Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Miyano S; M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
  • Ogawa S; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan; Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden.
  • Kanai T; Division of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Fukunaga K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Respir Investig ; 61(4): 454-459, 2023 Jul.
Article en En | MEDLINE | ID: mdl-37121116
ABSTRACT
We investigated the association between complete blood count, including neutrophil-to-lymphocyte ratio (NLR) in combination with patient characteristics, and coronavirus disease (COVID-19) outcomes to identify the best prognostic indicator. We analyzed data of patients with confirmed COVID-19 from the nationwide database of the Japan COVID-19 Task Force between February 2020 and November 2021. A composite outcome was defined as the most severe condition, including noninvasive positive-pressure ventilation, high-flow nasal cannula, invasive mechanical ventilation, extracorporeal membrane oxygenation, or death. Of 2425 patients in the analysis, 472 (19.5%) experienced a composite outcome. NLR was the best predictor of composite outcomes, with an area under the curve (AUC) of 0.81, and a sensitivity and specificity of 72.3% and 75.7%, respectively, using a cut-off value of 5.04. The combination of NLR and an oxygen requirement on admission had the highest AUC (0.88). This simple combination may help identify patients at risk of progression to severe disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Respir Investig Año: 2023 Tipo del documento: Article País de afiliación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Respir Investig Año: 2023 Tipo del documento: Article País de afiliación: Japón