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The efficacy of antibiotic-impregnated calcium sulfate (AICS) in the treatment of infected non-union and fracture-related infection: a systematic review.
Jacob, Connor C; Daw, Jad H; Santiago-Torres, Juan.
Afiliación
  • Jacob CC; Department of Orthopaedics, The Ohio State University College of Medicine, Columbus, OH 43201, USA.
  • Daw JH; Department of Orthopaedics, The Ohio State University College of Medicine, Columbus, OH 43201, USA.
  • Santiago-Torres J; Department of Orthopaedics, The Ohio State University College of Medicine, Columbus, OH 43201, USA.
J Bone Jt Infect ; 8(2): 91-97, 2023.
Article en En | MEDLINE | ID: mdl-37123503
Background: the treatment of infected non-union to allow for bony healing following orthopedic surgery remains a challenge. Antibiotic-impregnated calcium sulfate (AICS) is an effective vehicle for antibiotic delivery, but its efficacy in treating infected non-union in the setting of trauma and fracture remains unclear. Methods: this systematic review analyses nine studies from 2002 to 2022 that investigated AICS as a local antibiotic delivery system for cases of fracture-related infection and infected non-union. Results: in total, 214 patients who received AICS were included in this review. Of these patients, there were 154 cases of infected non-union or fracture-related infection. Across all studies analyzed, patients treated concurrently with AICS and systemic antibiotics experienced a 92.9 % rate of bony union and a 95.1 % rate of infection eradication. In addition, 100 % of the 13 patients who were treated with AICS alone experienced eradication of infection and successful bony union. Conclusion: AICS is an effective method of antibiotic delivery with a low risk profile that results in high rates of bony union and infection eradication even when used in the absence of systemic antibiotics.

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Systematic_reviews Idioma: En Revista: J Bone Jt Infect Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Systematic_reviews Idioma: En Revista: J Bone Jt Infect Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania