Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity.

Rinaldi, Capria; Waters, Christopher S; Li, Zizheng; Kumbier, Karl; Rao, Lee; Nichols, R Jeremy; Jacobson, Matthew P; Wu, Lani F; Altschuler, Steven J

Rinaldi, Capria; Waters, Christopher S; Li, Zizheng; Kumbier, Karl; Rao, Lee; Nichols, R Jeremy; Jacobson, Matthew P; Wu, Lani F; Altschuler, Steven J.

Afiliación

Rinaldi C; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Waters CS; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Li Z; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Kumbier K; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Rao L; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Nichols RJ; Department of Pathology, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.
Jacobson MP; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Wu LF; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: lani.wu@ucsf.edu.
Altschuler SJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: steven.altschuler@ucsf.edu.

Cell Rep ; 42(5): 112447, 2023 05 30.

Article en En | MEDLINE | ID: mdl-37141099

Asunto(s)

Proteínas Serina-Treonina Quinasas; Proteínas de Unión al GTP rab; Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina/genética; Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina/metabolismo; Proteínas Serina-Treonina Quinasas/genética; Proteínas Serina-Treonina Quinasas/metabolismo; Fosforilación; Mutación/genética; Proteínas de Unión al GTP rab/genética; Proteínas de Unión al GTP rab/metabolismo

Palabras clave

CP: Cell biology; LRRK2; Parkinson's disease; Rab phosphorylation; VPS34 inhibition; endosomal localization; positive feedback

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Serina-Treonina Quinasas / Proteínas de Unión al GTP rab Idioma: En Revista: Cell Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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