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A Series of Non-Oxido VIV Complexes of Dibasic ONS Donor Ligands: Solution Stability, Chemical Transformations, Protein Interactions, and Antiproliferative Activity.
Banerjee, Atanu; Patra, Sushree Aradhana; Sahu, Gurunath; Sciortino, Giuseppe; Pisanu, Federico; Garribba, Eugenio; Carvalho, M Fernanda N N; Correia, Isabel; Pessoa, João Costa; Reuter, Hans; Dinda, Rupam.
Afiliación
  • Banerjee A; Department of Chemistry, National Institute of Technology, Rourkela 769008, Odisha, India.
  • Patra SA; Department of Chemistry, National Institute of Technology, Rourkela 769008, Odisha, India.
  • Sahu G; Department of Chemistry, National Institute of Technology, Rourkela 769008, Odisha, India.
  • Sciortino G; Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Tarragona 43007, Spain.
  • Pisanu F; Dipartimento di Medicina, Chirurgia e Farmacia, Università di Sassari, Viale San Pietro, Sassari I-07100, Italy.
  • Garribba E; Dipartimento di Medicina, Chirurgia e Farmacia, Università di Sassari, Viale San Pietro, Sassari I-07100, Italy.
  • Carvalho MFNN; Centro de Química Estrutural and Departamento de Engenharia Química, Institute of Molecular Sciences, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, Lisboa 1049-001, Portugal.
  • Correia I; Centro de Química Estrutural and Departamento de Engenharia Química, Institute of Molecular Sciences, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, Lisboa 1049-001, Portugal.
  • Pessoa JC; Centro de Química Estrutural and Departamento de Engenharia Química, Institute of Molecular Sciences, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, Lisboa 1049-001, Portugal.
  • Reuter H; Institute of Chemistry of New Materials, University of Osnabrück, Barbarastraße 6, Osnabruck 49069, Germany.
  • Dinda R; Department of Chemistry, National Institute of Technology, Rourkela 769008, Odisha, India.
Inorg Chem ; 62(20): 7932-7953, 2023 May 22.
Article en En | MEDLINE | ID: mdl-37154533
ABSTRACT
A series of mononuclear non-oxido vanadium(IV) complexes, [VIV(L1-4)2] (1-4), featuring tridentate bi-negative ONS chelating S-alkyl/aryl-substituted dithiocarbazate ligands H2L1-4, are reported. All the synthesized non-oxido VIV compounds are characterized by elemental analysis, spectroscopy (IR, UV-vis, and EPR), ESI-MS, as well as electrochemical techniques (cyclic voltammetry). Single-crystal X-ray diffraction studies of 1-3 reveal that the mononuclear non-oxido VIV complexes show distorted octahedral (1 and 2) or trigonal prismatic (3) arrangement around the non-oxido VIV center. EPR and DFT data indicate the coexistence of mer and fac isomers in solution, and ESI-MS results suggest a partial oxidation of [VIV(L1-4)2] to [VV(L1-4)2]+ and [VVO2(L1-4)]-; therefore, all these three complexes are plausible active species. Complexes 1-4 interact with bovine serum albumin (BSA) with a moderate binding affinity, and docking calculations reveal non-covalent interactions with different regions of BSA, particularly with Tyr, Lys, Arg, and Thr residues. In vitro cytotoxic activity of all complexes is assayed against the HT-29 (colon cancer) and HeLa (cervical cancer) cells and compared with the NIH-3T3 (mouse embryonic fibroblast) normal cell line by MTT assay and DAPI staining. The results suggest that complexes 1-4 are cytotoxic in nature and induce cell death in the cancer cell lines by apoptosis and that a mixture of VIV, VV, and VVO2 species could be responsible for the biological activity.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complejos de Coordinación Límite: Animals / Humans Idioma: En Revista: Inorg Chem Año: 2023 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complejos de Coordinación Límite: Animals / Humans Idioma: En Revista: Inorg Chem Año: 2023 Tipo del documento: Article País de afiliación: India