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CD69 marks a subpopulation of acute myeloid leukemia with enhanced colony forming capacity and a unique signaling activation state.
Antony, Marie Lue; Chang, Daniel; Noble-Orcutt, Klara E; Kay, Anna; Jensen, Jeffrey L; Mohei, Hesham; Myers, Chad L; Sachs, Karen; Sachs, Zohar.
Afiliación
  • Antony ML; Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
  • Chang D; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
  • Noble-Orcutt KE; Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
  • Kay A; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
  • Jensen JL; Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
  • Mohei H; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
  • Myers CL; University of Michigan Medical School, Ann Arbor, MI, USA.
  • Sachs K; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Sachs Z; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Leuk Lymphoma ; 64(7): 1262-1274, 2023.
Article en En | MEDLINE | ID: mdl-37161853
Immunophenotypically-defined murine AML stem cells harbor self-renewing and non-self-renewing subsets that display unique signaling characteristics.CD69, an NFκB target gene, marks a subset of human AML with increased colony forming capacity and reduced proliferation.NFκB activation correlates with the global signaling pathway activation state in human AML.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos