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Thalamocortical coherence predicts persistent postconcussive symptoms.
Li, Yi-Tien; Kuo, Duen-Pang; Tseng, Philip; Chen, Yung-Chieh; Cheng, Sho-Jen; Wu, Changwei W; Hsieh, Li-Chun; Chiang, Yung-Hsiao; Chung, Hsiao-Wen; Lui, Yvonne W; Chen, Cheng-Yu.
Afiliación
  • Li YT; Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan; Neuroscience Research Center, Taipei Medical University, Taipei 11031, Taiwan.
  • Kuo DP; Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan; Department of Medical Imaging, Taipei Medical University Hospital, Taipei 11031, Taiwan.
  • Tseng P; Graduate Institute of Mind, Brain, and Consciousness, Taipei Medical University, Taipei 11031, Taiwan; Brain and Consciousness Research Center, Shuang-Ho Hospital, Taipei Medical University, New Taipei 23561, Taiwan; Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei 1
  • Chen YC; Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan; Department of Medical Imaging, Taipei Medical University Hospital, Taipei 11031, Taiwan.
  • Cheng SJ; Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan; Department of Medical Imaging, Taipei Medical University Hospital, Taipei 11031, Taiwan.
  • Wu CW; Graduate Institute of Mind, Brain, and Consciousness, Taipei Medical University, Taipei 11031, Taiwan; Brain and Consciousness Research Center, Shuang-Ho Hospital, Taipei Medical University, New Taipei 23561, Taiwan.
  • Hsieh LC; Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan; Department of Medical Imaging, Taipei Medical University Hospital, Taipei 11031, Taiwan; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
  • Chiang YH; Neuroscience Research Center, Taipei Medical University, Taipei 11031, Taiwan; Center for Neurotrauma and Neuroregeneration, Taipei Medical University, Taipei 11031, Taiwan; Department of Neurosurgery, Taipei Medical University Hospital, Taipei 11031, Taiwan; Department of Surgery, School of Medicin
  • Chung HW; Graduate Institute of Biomedical Electrics and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan.
  • Lui YW; Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY 10016, USA; Department of Radiology, NYU Grossman School of Medicine, New York University, New York, NY 10016, USA.
  • Chen CY; Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan; Department of Medical Imaging, Taipei Medical University Hospital, Taipei 11031, Taiwan; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan;
Prog Neurobiol ; 226: 102464, 2023 Jul.
Article en En | MEDLINE | ID: mdl-37169275
The pathogenetic mechanism of persistent post-concussive symptoms (PCS) following concussion remains unclear. Thalamic damage is known to play a role in PCS prolongation while the evidence and biomarkers that trigger persistent PCS have never been elucidated. We collected longitudinal neuroimaging and behavior data from patients and rodents after concussion, complemented with rodents' histological staining data, to unravel the early biomarkers of persistent PCS. Diffusion tensor imaging (DTI) were acquired to investigated the thalamic damage, while quantitative thalamocortical coherence was derived through resting-state functional MRI for evaluating thalamocortical functioning and predicting long-term behavioral outcome. Patients with prolonged symptoms showed abnormal DTI-derived indices at the boundaries of bilateral thalami (peri-thalamic regions). Both patients and rats with persistent symptoms demonstrated enhanced thalamocortical coherence between different thalamocortical circuits, which disrupted thalamocortical multifunctionality. In rodents, the persistent DTI abnormalities were validated in thalamic reticular nucleus (TRN) through immunohistochemistry, and correlated with enhanced thalamocortical coherence. Strong predictive power of these coherence biomarkers for long-term PCS was also validated using another patient cohort. Postconcussive events may begin with persistent TRN injury, followed by disrupted thalamocortical coherence and prolonged PCS. Functional MRI-based coherence measures can be surrogate biomarkers for early prediction of long-term PCS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Posconmocional Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Prog Neurobiol Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Posconmocional Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Prog Neurobiol Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido