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The histone H2B ubiquitination regulator Wac is essential for plasma cell differentiation.
Li, Yuxing; Ruan, Gui-Xin; Chen, Wenjing; Huang, Hengjun; Zhang, Rui; Wang, Jing; Ouyang, Yu; Zhu, Zhijian; Meng, Limin; Wang, Ruisi; Huo, Jianxin; Xu, Shengli; Ou, Xijun.
Afiliación
  • Li Y; School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
  • Ruan GX; Medical School, Taizhou University, Zhejiang, China.
  • Chen W; School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
  • Huang H; School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
  • Zhang R; School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
  • Wang J; School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
  • Ouyang Y; School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
  • Zhu Z; School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
  • Meng L; School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
  • Wang R; School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
  • Huo J; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore City, Singapore.
  • Xu S; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore City, Singapore.
  • Ou X; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
FEBS Lett ; 597(13): 1748-1760, 2023 07.
Article en En | MEDLINE | ID: mdl-37171241
ABSTRACT
Naïve B cells become activated and differentiate into antibody-secreting plasma cells (PCs) when encountering antigens. Here, we reveal that the WW domain-containing adapter protein with coiled-coil (Wac), which is important for histone H2B ubiquitination (ubH2B), is essential for PC differentiation. We demonstrate that B cell-specific Wac knockout mice have severely compromised T cell-dependent and -independent antibody responses. PC differentiation is drastically compromised despite undisturbed germinal center B cell response in the mutant mice. We also observe a significant reduction in global ubH2B in Wac-deficient B cells, which is correlated with downregulated expression of some genes critical for cell metabolism. Thus, our findings demonstrate an essential role of Wac-mediated ubH2B in PC differentiation and shed light on the epigenetic mechanisms underlying this process.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histonas / Proteínas Adaptadoras Transductoras de Señales Límite: Animals Idioma: En Revista: FEBS Lett Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histonas / Proteínas Adaptadoras Transductoras de Señales Límite: Animals Idioma: En Revista: FEBS Lett Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM